Actively Recruiting
Cognitive Disorders and Brain Pulse Assessment Using Tissue Pulsatility Imaging at MRRC
Led by University Hospital, Tours · Updated on 2026-05-06
300
Participants Needed
1
Research Sites
261 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on patients undergoing assessment for cognitive disorders at a memory, resources, and research centre (MRRC). It aims to study brain movements and pulsatility using a non-invasive ultrasound technique called Tissue Pulsatility Imaging (TPI) during routine care. The study involves a long-term follow-up of patients to understand changes in brain function related to neurocognitive disorders. Participants will receive an ultrasound examination as part of their day hospital visit at the MRRC. The TPI exam measures blood flow velocity in the middle cerebral artery and cerebral pulsatility using a standard ultrasound probe. The procedure takes 20 to 30 minutes and involves multiple short recordings while the patient lies down and then stands. This test is repeated annually for up to five years during follow-up visits. During the study, patients will be regularly assessed with TPI exams and other evaluations including neuropsychological measures, brain imaging, and biomarker tests. Researchers will measure brain movement amplitudes, pulsatility powers, hippocampal volume, and other brain health indicators yearly. Patient consent to data use is required, and the follow-up ensures ongoing monitoring of cognitive function and brain changes over time.
CONDITIONS
Brief Title
Cognitive Disorders and Brain Pulse
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient benefiting from a day hospital at the MRRC of the CHU of Tours for assessment of cognitive functions
You will not qualify if you...
- Refusal of TPI ultrasound examination
- Patients who opposed to data processing
- Patients under judicial protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during the day hospital assessment
Duration - At inclusion
Participants undergo an ultrasound examination using Tissue Pulsatility Imaging (TPI) to assess brain pulsatility and cognitive function. This non-invasive exam lasts about 20 to 30 minutes and is performed during routine day hospital care.
1 visit (in-person) during the day hospital stay
Duration - 5 years
Participants are followed up for 5 years with repeated TPI ultrasound examinations and cognitive assessments as part of their routine care at the MRRC day hospital or during new day hospital visits if necessary.
Annual visits for ultrasound and cognitive assessments
Trial Site Locations
Total: 1 location
1
University hospital
Tours, France, 37044
Actively Recruiting
Research Team
T
Thomas DESMIDT
D
Dominique BOMIA
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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