Actively Recruiting
Intervention Strategies to Improve Cognitive Functioning in Hematologic Cancer Survivors After Hematopoietic Cell Transplantation
Led by University of Alabama at Birmingham · Updated on 2026-04-20
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the feasibility of enrolling patients who have undergone hematopoietic cell transplantation (HCT) to improve their neurocognitive function using the Lumosity cognitive training program. This pilot study also aims to assess patients' interest in receiving genetic risk information related to cognitive impairment after HCT. Understanding patient preferences regarding genetic risk communication is important as personalized medicine advances. The study uses the Lumosity program, an online cognitive training tool with over 60 game-like tasks targeting processing speed, working memory, and executive function. Participants will engage in daily sessions of five training tasks for 12 weeks. The study has two groups: one starts the Lumosity program immediately upon enrollment, while the other begins after a 3-month waiting period. Customized performance reports are generated each time participants complete a session. Participants will be monitored over 12 weeks to measure cognitive function changes between the two groups. Surveys will assess genetic knowledge and attitudes toward receiving genetic risk information. Data collection includes cognitive performance reports and questionnaires on genetic understanding, the importance of genetic information, and its impact on intervention uptake and adherence. The study's total participation duration is 12 weeks.
CONDITIONS
Brief Title
Cognitive Training Intervention and Attitudes Towards Genetics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 years old or older at time of allogeneic hematopoietic cell transplantation performed at UAB
- Outpatient and between 3 and 6 months post hematopoietic cell transplantation
- English speaking
- Access to an internet-connected home computer
You will not qualify if you...
- History of pre-existing neurological disorder or documented major psychiatric disorder
- Significant auditory, visual, or motor impairments
- Participated in neuropsychological intervention within the past 6 months
- History of color blindness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants complete daily sessions of the Lumosity cognitive training program for 12 weeks to improve cognitive functioning.
Daily sessions at home; 1 baseline visit and 1 follow-up visit
Duration - 12 weeks plus 12-week wait period
Participants in the waitlist control group begin the Lumosity program after a 12-week waiting period, completing daily sessions for 12 weeks.
Daily sessions at home; 1 baseline visit and 1 follow-up visit
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
Actively Recruiting
Research Team
N
Noha M Sharafeldin, MD,MSc, PhD
L
Lindsey Hageman, MPH
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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