Study to Collect Virus Secretions and Blood Samples for COVID-19 and Other Respiratory Virus Research and Long-Term Health Effects

What this Trial Is About

Researchers are conducting an observational study to better understand how SARS-CoV-2 infections develop and affect people over time, including those with other respiratory viruses. The study aims to track virus shedding, immune responses, and long-term health effects known as post-acute sequelae of SARS-CoV-2 PASC. This includes monitoring antibody responses and identifying factors that influence disease severity and recovery. The research also seeks to help improve screening, treatment, and prevention strategies for COVID-19 and similar infections. Participants include those recently diagnosed with COVID-19 and other respiratory viruses, as well as individuals who may have been exposed and developed antibodies without confirmed diagnosis. The study collects blood and virus samples to analyze viral genetics, immune responses, and inflammatory markers. Two groups are involved one with active or recent infections, and another with past infections or possible exposure. Consent is obtained verbally or in writing as appropriate. Throughout participation, individuals provide samples and clinical information at multiple time points to assess symptoms and outcomes up to two years after infection. The study measures include severity of COVID-19 cases and onset of post-COVID symptoms at intervals from 3 months to 24 months. Data collected will help identify predictors of long-term effects and support future treatment development. Participants may be monitored for changes in health status and immune responses during the follow-up period.

Collection of SARS CoV-2 (COVID-19) Virus Secretions and Serum for Countermeasure Development