Study Comparing Immune Responses After COVID-19 Infection and Vaccination in Adults

What this Trial Is About

Researchers are studying and comparing the immune responses in people after natural infection with SARS-CoV-2 and after receiving COVID-19 vaccination. This observational study aims to understand differences in antibody responses, B and T cell responses, and any short- or long-term complications following infection or vaccination. It also explores if prior infection affects the immune response to vaccination and the occurrence of reinfections. The study includes groups of health care workers and patient populations prioritized for vaccination, with approximately 500-1000 health care workers and 2000 patients expected to participate. Participants will be observed based on their vaccination status or natural infection. Blood samples and clinical data will be collected repeatedly to assess immune responses over time, from 2 months up to 3 years. Participants will provide demographic and clinical information and undergo repeated blood sampling to measure immune markers and evaluate complications related to COVID-19 infection or vaccination. The primary outcome is the immune response measured over 2 months to 3 years. Secondary outcomes include the duration and breadth of B-cell and T-cell responses. The study will monitor participants health throughout this period to gather comprehensive immune and clinical data.

Comparison of the Immune Response to Natural COVID-19 Infection and Vaccination