Covid-19 Effects on Arterial Stiffness and Vascular Aging

What this Trial Is About

Researchers are investigating the effects of COVID-19 infection on early vascular aging by studying arterial stiffness and related cardiovascular changes. The study evaluates these effects at 6 months and 12 months after infection, including patients with varying severity of COVID-19, from those hospitalized in intensive care to those not requiring hospitalization, as well as individuals who tested negative for the virus. The study aims to understand vascular and cardiac function changes and long-term cardiovascular events and mortality over several years. Participants undergo non-invasive vascular and cardiac assessments, including measurements of carotid-femoral pulse-wave velocity and other vascular tests, at 6 and 12 months following COVID-19 infection or testing. The study groups include patients hospitalized in intensive care, those hospitalized in medicine units, patients with mild or no hospitalization, and a control group with negative SARS-CoV-2 tests. Cardiovascular events and mortality data will be collected at 2, 5, and 10 years after enrollment. During the study, participants will have vascular and cardiac function tests to measure arterial stiffness, arterial distensibility, blood pressure, and cardiac function at specified time points. Researchers will track changes between 6 and 12 months after infection to assess progression or improvement. Long-term follow-up includes tracking cardiovascular events and mortality over up to 10 years. Participants provide written informed consent and must be able to attend scheduled visits for assessments.

Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)