Actively Recruiting
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
Led by Mirati Therapeutics Inc. · Updated on 2025-08-17
90
Participants Needed
166
Research Sites
210 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation
CONDITIONS
Official Title
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Untreated and unresectable or metastatic NSCLC with histologically confirmed KRAS G12C mutation
- For Cohort A: PD-L1 TPS 1% or higher
- For Cohorts C and E: PD-L1 TPS less than 50%
- For Cohort C: Previously completed 4 cycles of platinum-based induction chemotherapy with pembrolizumab with stable disease, partial response, or complete response, or stopped early due to toxicity
- Presence of measurable disease according to RECIST v1.1
You will not qualify if you...
- Any prior therapy targeting KRAS G12C mutation
- For Cohorts A and E: Prior systemic therapy for locally advanced or metastatic NSCLC including chemotherapy or immune checkpoint inhibitor therapy, except prior adjuvant or neoadjuvant therapy completed over 1 year ago
- For Cohort C: Received maintenance therapy following first-line platinum-based regimen
- Radiation to the lung exceeding 30 Gy within 6 months before study treatment
- Active brain metastases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 166 locations
1
Local Institution - Unk025
Anchorage, Alaska, United States, 99508
Active, Not Recruiting
2
Local Institution - 017-591
Glendale, Arizona, United States, 85304
Withdrawn
3
Local Institution - 017-821
Phoenix, Arizona, United States, 85004
Withdrawn
4
Local Institution - Unk047
Anaheim, California, United States, 92805
Active, Not Recruiting
5
Local Institution - 017-936C
Fountain Valley, California, United States, 92708
Not Yet Recruiting
6
MemorialCare - Orange Coast Medical Center
Fountain Valley, California, United States, 92708
Actively Recruiting
7
Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton
Fullerton, California, United States, 92835
Actively Recruiting
8
Local Institution - Unk004
Loma Linda, California, United States, 92354
Active, Not Recruiting
9
Local Institution - 017-961
Los Angeles, California, United States, 90095
Withdrawn
10
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States, 94158
Actively Recruiting
11
Local Institution - 017-872-I
Aurora, Colorado, United States, 80012
Not Yet Recruiting
12
Local Institution - 017-872-G
Boulder, Colorado, United States, 80303
Not Yet Recruiting
13
Local Institution - 017-872-D
Colorado Springs, Colorado, United States, 80907
Not Yet Recruiting
14
Local Institution - 017-872-J
Colorado Springs, Colorado, United States, 80920
Not Yet Recruiting
15
Local Institution - 017-872-B
Denver, Colorado, United States, 80218
Not Yet Recruiting
16
Local Institution - 017-872-F
Denver, Colorado, United States, 80220
Not Yet Recruiting
17
Local Institution - 017-872-A
Lakewood, Colorado, United States, 80228
Not Yet Recruiting
18
Local Institution - 017-872-C
Littleton, Colorado, United States, 80218
Not Yet Recruiting
19
USOR - Rocky Mountain Cancer Centers - Lone Tree - Sky Ridge Medical Center
Lone Tree, Colorado, United States, 80124
Actively Recruiting
20
Local Institution - 017-872-E
Pueblo, Colorado, United States, 81003
Not Yet Recruiting
21
Local Institution - 017-872-H
Thornton, Colorado, United States, 80260
Not Yet Recruiting
22
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224
Actively Recruiting
23
The Oncology Institute of Hope and Innovation - Lakeland
Lakeland, Florida, United States, 33812
Actively Recruiting
24
Local Institution - Unk076
Miami, Florida, United States, 33136
Active, Not Recruiting
25
Local Institution - Unk055
Orlando, Florida, United States, 32803
Active, Not Recruiting
26
Local Institution - Unk062
Chicago, Illinois, United States, 60612
Active, Not Recruiting
27
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
28
Local Institution - 017-820J
Fairway, Kansas, United States, 66205
Not Yet Recruiting
29
Local Institution - 017-820A
Kansas City, Kansas, United States, 66160
Not Yet Recruiting
30
Local Institution - 017-820B
Kansas City, Kansas, United States, 66160
Not Yet Recruiting
31
Local Institution - 017-820C
Kansas City, Kansas, United States, 66160
Not Yet Recruiting
32
Local Institution - 017-820H
Kansas City, Kansas, United States, 66160
Not Yet Recruiting
33
Local Institution - 017-820I
Overland Park, Kansas, United States, 66210
Not Yet Recruiting
34
University of Kansas Cancer Center - Westwood/Richard and Annette Bloch Cancer Care Pavilion
Westwood, Kansas, United States, 66205
Actively Recruiting
35
Local Institution - 017-965
Lexington, Kentucky, United States, 40503
Withdrawn
36
Local Institution - Unk009
Baltimore, Maryland, United States, 21201
Active, Not Recruiting
37
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02115
Actively Recruiting
38
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
39
Local Institution - Unk039
Burlington, Massachusetts, United States, 01803
Active, Not Recruiting
40
Local Institution - Unk069
Detroit, Michigan, United States, 48201
Active, Not Recruiting
41
Local Institution - Unk018
Lansing, Michigan, United States, 488912
Active, Not Recruiting
42
Henry Ford Medical Center - Columbus
Novi, Michigan, United States, 48377
Actively Recruiting
43
Local Institution - 017-838B
Minneapolis, Minnesota, United States, 55404
Not Yet Recruiting
44
Local Institution - 017-838C
Minneapolis, Minnesota, United States, 55404
Not Yet Recruiting
45
Mayo Clinic - Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
46
Metro-Minnesota Community Oncology Research Consortium (MMCORC)
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
47
Local Institution - 017-838A
Saint Louis Park, Minnesota, United States, 55426-5000
Not Yet Recruiting
48
Local Institution - 017-820F
Kansas City, Missouri, United States, 64116
Not Yet Recruiting
49
Local Institution - 017-820E
Kansas City, Missouri, United States, 64154
Not Yet Recruiting
50
Local Institution - 017-820D
Lee's Summit, Missouri, United States, 64064
Not Yet Recruiting
51
Local Institution - 017-820G
North Kansas City, Missouri, United States, 64116
Not Yet Recruiting
52
Local Institution - Unk008
Osage Beach, Missouri, United States, 65065
Active, Not Recruiting
53
Local Institution - Unk058
Springfield, Missouri, United States, 65807
Active, Not Recruiting
54
Local Institution - 017-080
Babylon, New York, United States, 11702
Not Yet Recruiting
55
Local Institution - 017-088
Brooklyn, New York, United States, 11210
Not Yet Recruiting
56
Hematology-Oncology Associates of Central New York - Brittonfield - East Syracuse
East Syracuse, New York, United States, 13057
Actively Recruiting
57
Local Institution - 017-087
New Hyde Park, New York, United States, 11042
Not Yet Recruiting
58
Local Institution - 017-085
New York, New York, United States, 10028
Not Yet Recruiting
59
Local Institution - 017-082
Patchogue, New York, United States, 11772
Not Yet Recruiting
60
Local Institution - 017-086
Port Jefferson, New York, United States, 11776
Not Yet Recruiting
61
Local Institution - 017-081
Port Jefferson Station, New York, United States, 11776
Not Yet Recruiting
62
New York Cancer & Blood Specialists - Cancer Center - Research Headquarters
Port Jefferson Station, New York, United States, 11776
Actively Recruiting
63
Local Institution - 017-084
Riverhead, New York, United States, 11901
Not Yet Recruiting
64
Local Institution - 017-945
The Bronx, New York, United States, 10467
Withdrawn
65
Local Institution - 017-083
The Bronx, New York, United States, 10469
Not Yet Recruiting
66
Cleveland Clinic Main Campus
Cleveland, Ohio, United States, 44195
Actively Recruiting
67
Local Institution - 017-836
Kettering, Ohio, United States, 45429
Withdrawn
68
Local Institution - 017-916
Memphis, Tennessee, United States, 38104
Withdrawn
69
Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States, 75246
Actively Recruiting
70
Local Institution - Unk056
Dallas, Texas, United States, 75390
Active, Not Recruiting
71
Local Institution - 017-848
Houston, Texas, United States, 77030
Withdrawn
72
Local Institution - 017-999
Irving, Texas, United States, 75063
Not Yet Recruiting
73
USOR - Texas Oncology Northeast Texas - Longview Cancer Center
Longview, Texas, United States, 75601
Actively Recruiting
74
Local Institution - 017-878-B
Palestine, Texas, United States, 75801
Not Yet Recruiting
75
Local Institution - 017-878-C
Paris, Texas, United States, 75460
Not Yet Recruiting
76
Local Institution - 017-878-A
Tyler, Texas, United States, 75702
Not Yet Recruiting
77
Local Institution - Unk010
Salt Lake City, Utah, United States, 84106
Active, Not Recruiting
78
Local Institution - 017-814-A
Arlington, Virginia, United States, 22205
Not Yet Recruiting
79
Local Institution - Unk066
Fairfax, Virginia, United States, 22031
Active, Not Recruiting
80
Virginia Cancer Specialists - Fairfax Office
Fairfax, Virginia, United States, 22031
Actively Recruiting
81
Local Institution - 017-814-B
Gainesville, Virginia, United States, 20155
Not Yet Recruiting
82
Local Institution - 017-814-C
Reston, Virginia, United States, 20190
Not Yet Recruiting
83
PeaceHealth St. Joseph Medical Center
Bellingham, Washington, United States, 98225
Actively Recruiting
84
Local Institution - Unk036
Huntington, West Virginia, United States, 25705
Active, Not Recruiting
85
Local Institution - 017-458
Natal, Rio Grande do Norte, Brazil, 59062-000
Withdrawn
86
Local Institution - 017-446
Ijuí, Rio Grande do Sul, Brazil, 98700-000
Withdrawn
87
Local Institution - 017-453
Itajaí, Santa Catarina, Brazil, 88301-220
Withdrawn
88
Local Institution - 017-457
Barretos, Brazil, 14784-400
Withdrawn
89
Local Institution - 017-442
Curitiba, Brazil, 81520-060
Withdrawn
90
Local Institution - 017-452
Fortaleza, Brazil, 60810-180
Withdrawn
91
Local Institution - 017-455
Jaú, Brazil, 17210-180
Withdrawn
92
Local Institution - 017-454
Rio de Janeiro, Brazil, 22250-905
Withdrawn
93
Local Institution - 017-456
São Paulo, Brazil, 01246-000
Withdrawn
94
Local Institution - 017-695
Viña del Mar, Valparaiso, Chile, 2520612
Withdrawn
95
Local Institution - 017-697
Providencia, Chile, 7500006
Withdrawn
96
Local Institution - 017-696
Santiago, Chile, 0
Withdrawn
97
Local Institution - 017-698
Temuco, Chile, 4810469
Withdrawn
98
Institut de Cancerologie de lOuest - Angers
Angers, France, 49055
Actively Recruiting
99
Centre Francois Baclesse
Caen, France, 14076
Actively Recruiting
100
Centre Hospitalier Intercommunal de Creteil
Créteil, France, 94000
Actively Recruiting
101
Centre Georges Francois Leclerc
Dijon, France, 21079
Actively Recruiting
102
Hopital Michallon
La Tronche, France, 38700
Actively Recruiting
103
Local Institution - 017-688
Lille, France, 59000
Withdrawn
104
Local Institution - Unk078
Lyon, France, 69008
Active, Not Recruiting
105
Institut Paoli-Calmettes
Marseille, France, 13009
Actively Recruiting
106
Local Institution - Unk067
Marseille, France, 13015
Active, Not Recruiting
107
Local Institution - 017-200
Montpellier, France, 34090
Withdrawn
108
Local Institution - Unk029
Paris, France, 75018
Active, Not Recruiting
109
Hopital Tenon
Paris, France, 75020
Actively Recruiting
110
Local Institution - 017-664
Paris, France, 75248
Withdrawn
111
Local Institution - 017-198
Saint-Herblain, France, 44805
Withdrawn
112
Hopital Foch
Suresnes, France, 92150
Actively Recruiting
113
Hopital Larrey
Toulouse, France, 31059
Actively Recruiting
114
Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
115
Local Institution - 017-790
Batumi, Georgia, 6000
Withdrawn
116
Local Institution - 017-789
Tbilisi, Georgia, 0144
Withdrawn
117
Local Institution - 017-794
Tbilisi, Georgia, 0159
Withdrawn
118
Local Institution - 017-791
Tbilisi, Georgia, 0177
Withdrawn
119
Local Institution - 017-792
Tbilisi, Georgia, 0259
Withdrawn
120
Local Institution - 017-793
Tbilisi, Georgia, 380077
Withdrawn
121
University General Hospital of Heraklion (PAGNI)
Heraklion, Greece, 71110
Actively Recruiting
122
University General Hospital of Larissa
Larissa, Greece, 41110
Actively Recruiting
123
Metropolitan Hospital
Piraeus, Greece, 185 47
Actively Recruiting
124
Orszagos Koranyi Pulmonologiai Intezet
Budapest, Hungary, 1121
Actively Recruiting
125
Orszagos Onkologiai Intezet
Budapest, Hungary, 1122
Actively Recruiting
126
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
Székesfehérvár, Hungary, 8000
Actively Recruiting
127
Reformatus Pulmonologiai Centrum
Törökbálint, Hungary, 2045
Actively Recruiting
128
Local Institution - 017-767 - B
Faenza, Ravenna, Italy, 48018
Not Yet Recruiting
129
Local Institution - 017-767 - A
Lugo, Ravenna, Italy, 48022
Not Yet Recruiting
130
Azienda Ospedaliera San Giuseppe Moscati - Avellino
Avellino, Italy, 83100
Actively Recruiting
131
Local Institution - 017-274
Aviano, Italy, 33081
Not Yet Recruiting
132
Ospedale Santo Spirito
Casale Monferrato, Italy, 15033
Actively Recruiting
133
Azienda Ospedaliero - Universitaria Careggi
Florence, Italy, 50134
Actively Recruiting
134
Istituto Europeo di Oncologia
Milan, Italy, 20141
Actively Recruiting
135
Azienda Ospedaliero - Universitaria San Luigi Gonzaga
Orbassano, Italy, 10043
Actively Recruiting
136
Local Institution - 017-297
Padova, Italy, 35128
Withdrawn
137
Ospedale Santa Maria delle Croci di Ravenna
Ravenna, Italy, 48121
Actively Recruiting
138
IRCCS Istituto Nazionale Tumori Regina Elena
Roma, Italy, 00144
Actively Recruiting
139
Local Institution - 017-280
Roma, Italy, 00168
Active, Not Recruiting
140
Local Institution - 017-076
Kota Bharu, Kelantan, Malaysia, 15586
Withdrawn
141
Local Institution - 017-075
Kuantan, Pahang, Malaysia, 25100
Withdrawn
142
Local Institution - 017-073
Kuala Lumpur, Malaysia, 50586
Withdrawn
143
Local Institution - 017-072
Putrajaya, Malaysia, 62250
Withdrawn
144
Local Institution - 017-381
Konin, Poland, 62-500
Withdrawn
145
Instytut MSF
Lodz, Poland, 90-302
Actively Recruiting
146
Med Polonia Sp. z o. o. - Obornicka
Poznan, Poland, 60-693
Actively Recruiting
147
Wojskowy Instytut Medyczny
Warsaw, Poland, 04-349
Actively Recruiting
148
Local Institution - 017-692
Belgrade, Serbia, 11000
Withdrawn
149
Local Institution - 017-693
Belgrade, Serbia, 11000
Withdrawn
150
Local Institution - 017-690
Belgrade, Serbia, 11080
Withdrawn
151
Local Institution - 017-691
Kamenitz, Serbia, 21204
Withdrawn
152
Local Institution - 017-694
Kragujevac, Serbia, 34000
Withdrawn
153
Complejo Hospitalario Universitario A Coruna
A Coruña, Spain, 15006
Actively Recruiting
154
Hospital General Universitario Gregorio Maranon
Madrid, Spain, 28007
Actively Recruiting
155
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
156
Hospital Universitario Puerta de Hierro - Majadahonda
Majadahonda, Spain, 28222
Actively Recruiting
157
Local Institution - Unk001
Málaga, Spain, 29010
Active, Not Recruiting
158
Hospital Universitario Son Espases
Palma de Mallorca, Spain, 07120
Actively Recruiting
159
Hospital Son Llatzer
Palma de Mallorca, Spain, 07198
Actively Recruiting
160
Hospital Universitario Virgen Macarena
Seville, Spain, 41009
Actively Recruiting
161
Hospital Clinico Universitario Lozano Blesa
Zaragoza, Spain, 50009
Actively Recruiting
162
Local Institution - 017-395
Geneva, Switzerland, 1205
Withdrawn
163
Local Institution - 017-132
Bang Phlat, Thailand, 10700
Withdrawn
164
Local Institution - 017-136
Bangkok, Thailand, 10400
Withdrawn
165
Local Institution - 017-135
Chom Thong, Thailand, 50200
Withdrawn
166
Local Institution - 017-137
Khon Kaen, Thailand, 40002
Withdrawn
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain the NCT# and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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