Study of Combined Anodal Transcranial Direct Current Stimulation and Cognitive Training to Improve Decision-making and Impulsivity in Healthy Adults Aged 18 to 40

What this Trial Is About

This research aims to study the effects of combining anodal transcranial direct current stimulation tDCS with cognitive training on decision-making and motor impulsivity in healthy adults aged 18 to 40. The study explores whether this combination leads to better decision-making on the Iowa Gambling Task IGT and improved impulse control compared to a sham tDCS with cognitive training. The trial addresses gaps in understanding how brain stimulation and training influence decision-making under risk and if these effects apply to motor impulsivity. Participants will be randomly assigned to one of two groups one receiving active anodal tDCS combined with cognitive training using the Iowa Gambling Task, and the other receiving sham tDCS with the same cognitive training. The active tDCS involves a 2mA current applied over the anterior frontal cortex, including the ventromedial prefrontal cortex, for 20 minutes during the task. Sham stimulation mimics the procedure but only delivers current briefly at the start. Both groups complete the cognitive training during these sessions. During the study, participants decision-making will be assessed by changes in the IGT scores before and after the combined treatment. Motor impulsivity will be measured using the Stop Signal Task, and impulsive behavior traits will be evaluated with the UPPSP scale. Mood states are also monitored before and after stimulation. The trial is single-blind and includes healthy volunteers, with all assessments conducted to evaluate changes in behavior and cognition after the intervention.

Combined Anodal Transcranial Direct Current Stimulation (tDCS) and Cognitive Training and Decision-making