Actively Recruiting

Phase Not Applicable
Age: 1Year - 5Years
All Genders
Healthy Volunteers
ID06612125

Comparison of Positive Pressure Ventilation Methods in Young Children Undergoing Laparoscopic Inguinal Hernia Repair Using a Laryngeal Mask Airway

Led by Beni-Suef University · Updated on 2025-01-09

78

Participants Needed

1

Research Sites

25 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research compares different positive pressure ventilation strategies for children aged 1 to 5 years undergoing laparoscopic inguinal hernia repair using a laryngeal mask airway (LMA). The study focuses on three ventilation modes: volume-controlled ventilation (VCV), pressure-controlled ventilation (PCV), and pressure-controlled volume-guaranteed ventilation (PCV-VG). It aims to understand how these methods affect airway pressures and ventilation volumes during anesthesia, given the unique advantages and challenges of each mode in pediatric airway management. Children in the study are randomly assigned to one of three ventilation groups. The VCV group receives a set tidal volume of 7 mL/kg with a respiratory rate of 16 breaths per minute and a 1:2 inspiratory-to-expiratory ratio. The PCV group uses pressure-controlled ventilation with peak inspiratory pressure adjusted to reach a tidal volume of 7 mL/kg, a respiratory rate of 16 breaths per minute, and a 1:2 ratio, with a PIP limit of 20 cm H2O. The PCV-VG group combines pressure control and volume guarantee, also set to a tidal volume of 7 mL/kg with the same respiratory rate and ratio. Participants are monitored for key respiratory parameters within one hour, including peak inspiratory pressure, plateau pressure, dynamic compliance, airway resistance, tidal volume, end-tidal CO2, and dead space to tidal volume ratio. The trial assesses the effectiveness and safety of each ventilation strategy during surgery. Total participation involves preoperative evaluation, anesthesia with assigned ventilation, and close monitoring of respiratory function to compare outcomes across the three ventilation approaches.

CONDITIONS

Official Title

Comparing Different Startegies of Positive Pressure Ventilation in Children

Who Can Participate

Age: 1Year - 5Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 1 and 5 years
  • Scheduled for laparoscopic inguinal hernia repair
  • American Society of Anesthesiologists physical status classification I or II
Not Eligible

You will not qualify if you...

  • Cardiopulmonary disease
  • Severe liver or kidney dysfunction
  • Upper respiratory tract infection within 2 weeks before surgery
  • Overweight by more than 20% of standard body weight
  • Neuromuscular disease
  • Anticipated difficult airway
  • Hiatus hernia or gastroesophageal reflux disease

AI-Screening

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Trial Site Locations

Total: 1 location

1

Benisuef university hospital

Benisuef, Egypt

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Research Team

M

Mariana AS Mansour, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

SEQUENTIAL

Primary Purpose

OTHER

Number of Arms

3

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