Actively Recruiting
Comparison of Positive Pressure Ventilation Methods in Young Children Undergoing Laparoscopic Inguinal Hernia Repair Using a Laryngeal Mask Airway
Led by Beni-Suef University · Updated on 2025-01-09
78
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research compares different positive pressure ventilation strategies for children aged 1 to 5 years undergoing laparoscopic inguinal hernia repair using a laryngeal mask airway (LMA). The study focuses on three ventilation modes: volume-controlled ventilation (VCV), pressure-controlled ventilation (PCV), and pressure-controlled volume-guaranteed ventilation (PCV-VG). It aims to understand how these methods affect airway pressures and ventilation volumes during anesthesia, given the unique advantages and challenges of each mode in pediatric airway management. Children in the study are randomly assigned to one of three ventilation groups. The VCV group receives a set tidal volume of 7 mL/kg with a respiratory rate of 16 breaths per minute and a 1:2 inspiratory-to-expiratory ratio. The PCV group uses pressure-controlled ventilation with peak inspiratory pressure adjusted to reach a tidal volume of 7 mL/kg, a respiratory rate of 16 breaths per minute, and a 1:2 ratio, with a PIP limit of 20 cm H2O. The PCV-VG group combines pressure control and volume guarantee, also set to a tidal volume of 7 mL/kg with the same respiratory rate and ratio. Participants are monitored for key respiratory parameters within one hour, including peak inspiratory pressure, plateau pressure, dynamic compliance, airway resistance, tidal volume, end-tidal CO2, and dead space to tidal volume ratio. The trial assesses the effectiveness and safety of each ventilation strategy during surgery. Total participation involves preoperative evaluation, anesthesia with assigned ventilation, and close monitoring of respiratory function to compare outcomes across the three ventilation approaches.
CONDITIONS
Official Title
Comparing Different Startegies of Positive Pressure Ventilation in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 1 and 5 years
- Scheduled for laparoscopic inguinal hernia repair
- American Society of Anesthesiologists physical status classification I or II
You will not qualify if you...
- Cardiopulmonary disease
- Severe liver or kidney dysfunction
- Upper respiratory tract infection within 2 weeks before surgery
- Overweight by more than 20% of standard body weight
- Neuromuscular disease
- Anticipated difficult airway
- Hiatus hernia or gastroesophageal reflux disease
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Trial Site Locations
Total: 1 location
1
Benisuef university hospital
Benisuef, Egypt
Actively Recruiting
Research Team
M
Mariana AS Mansour, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
OTHER
Number of Arms
3
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