Actively Recruiting
Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
Led by University Health Network, Toronto · Updated on 2025-03-06
10
Participants Needed
1
Research Sites
161 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to the lungs via a breathing machine greater the brain activity and also the greater the injury to the brain cells. There is no study in humans that investigates the physiological communication between the volume of air delivered to the lungs and brain activity. This is important because really sick patients receive breathing assistance using breathing machines to keep their oxygen levels within a normal range. Although these machines are life-saving tools, they might result in brain cell injury, leading to cognitive impairment. So, establishing the existence of a physiological communication between the volume of air delivered using these breathing machines and brain activity is the first step to investigating therapies to prevent brain cell injury due to the use of breathing machines to assist breathing.
CONDITIONS
Official Title
Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled to undergo an MRI scan of their head under general anesthesia
- Age greater than 18 years
You will not qualify if you...
- Stroke or brain tumor in the regions of interest not diagnosed before the MRI scan
- Previous medical history of dementia
- Previous medical history of brain surgery
- Acute or chronic spinal cord injury
- Previous vagotomy
- Phrenic nerve injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2N2
Actively Recruiting
Research Team
R
Rongyu ( Cindy) Jin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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