A Randomized Trial Comparing Pain Relief Using Mirogabalin or Pregabalin After Primary Total Knee Replacement Surgery

What this Trial Is About

This research aims to compare the effectiveness of two pain relief drugs, mirogabalin and pregabalin, after unilateral primary total knee arthroplasty TKA in adults aged 50 to 85 years. The study evaluates which drug better reduces pain and improves function following knee replacement surgery. It is a randomized controlled trial conducted by Thammasat University Hospital. After surgery, participants are randomly assigned to receive either mirogabalin or pregabalin alongside standard medications. Those in the mirogabalin group take 5 mg tablets twice a day after breakfast and dinner for two weeks. Participants in the pregabalin group take 75 mg tablets once daily before bedtime for two weeks. During the study, participants pain scores will be measured frequently, starting every six hours for two days, then twice daily for two weeks, and weekly up to 12 weeks after surgery. Researchers will also monitor morphine use, knee movement range, knee function scores, sedation levels, incidence of sleepiness and dizziness, and hospital stay length. The total participation lasts up to 12 weeks post-surgery, with regular assessments to track recovery and safety.

Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA