Comparison of Clarus and Optos Ultrawide Field Imaging Systems to Standard Imaging for Inherited Retinal Disease

What this Trial Is About

This research study focuses on inherited retinal diseases IRDs and aims to compare two ultrawide field imaging cameras, Clarus and Optos, against the standard Spectralis imaging system. The goal is to determine if all these cameras provide the same results and information for evaluating and monitoring IRDs. The study is sponsored by the University of Wisconsin, Madison, and involves adult participants diagnosed clinically or genetically with IRD. Participants will undergo pupillary dilation followed by photographs taken of the inside of their eyes using three different camera systems Spectralis FAF imaging, Optos imaging, and Clarus imaging. Spectralis captures 20-55 degrees of the retina using blue light, while Optos and Clarus provide ultrawide field images covering up to 200 degrees with different light excitation methods. During the study visit, researchers will compare fundus autofluorescence FAF retinal patterns across the three cameras and evaluate abnormalities unique to IRD. Each imaging session lasts up to 2 hours. The study measures how well the ultrawide field cameras capture retinal changes beyond the standard imaging field and assesses other autofluorescence abnormalities. Participants are monitored for their ability to tolerate imaging, and the study takes place over a single visit.

COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal Disease