Actively Recruiting
Establishment of a Multimodal Standard Database for Inflammation-related Ophthalmopathy
Led by Dan Chen · Updated on 2026-06-05
3000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting an observational study to explore the links between common blinding retinal diseases like diabetic retinopathy, pathological myopia, and age-related macular degeneration, and changes in the fine structures of the front part of the eye. The study aims to understand these connections deeply by collecting detailed data using advanced imaging technologies. The goal is to build a comprehensive eye image database that could help identify early warning signs and support future AI-assisted diagnosis and treatment models. Participants will undergo multimodal imaging of both the eye surface and the retina using technologies such as Ultra-Widefield fundus photography, OCT/OCTA, adaptive optics scanning laser ophthalmoscopy, corneal confocal microscopy, and tests assessing meibomian gland function, corneal sensitivity, and tear film function. Participants will be grouped based on inflammatory-related ocular diseases or non-inflammatory-related ocular diseases, with data collected at baseline and within 30 days post-examination. During the study, participants will have their eye condition assessed through multiple measures including tear break-up time, dry eye questionnaires, blink rate, lipid layer thickness, and tear meniscus height, along with retinal thickness and fluid presence. Medical records and follow-up information will be collected to support analyses. The study will monitor these parameters carefully to build a standardized database to aid diagnostics. Participation may last up to several months depending on follow-up availability.
CONDITIONS
Brief Title
Establishment of a Multimodal Standard Database for Inflammation-related Ophthalmopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with retinal vascular or metabolic diseases such as diabetic retinopathy, retinal vein occlusion, or hypertensive retinopathy
- Diagnosed with degenerative diseases like age-related macular degeneration, pathological myopia, or polypoidal choroidal vasculopathy
- Diagnosed with immune-mediated or inflammatory eye diseases including uveitis, optic neuritis, Mooren's ulcer, or corneal melting linked to systemic immune diseases
- Diagnosed with anterior segment and ocular surface syndromes such as dry eye disease, keratoconus, or glaucoma with chronic inflammation or long-term medication use
- Diagnosed with developmental fundus diseases in children or adolescents including Coats' disease, familial exudative vitreoretinopathy, or retinopathy of prematurity
- Confirmed diagnosis of fundus diseases like diabetic retinopathy, pathological myopia, or age-related macular degeneration
- Able to cooperate with advanced eye examinations and imaging techniques with acceptable image quality
- Availability of complete or accessible ophthalmic medical records
- Blood pressure less than or equal to 160/100 mmHg
You will not qualify if you...
- Recent corneal or conjunctival acute inflammation, ocular surgery, or trauma within the past 3 months
- Presence of corneal changes such as those caused by contact lens wear
- Fundus images that are unclear or severely obscured, such as from vitreous hemorrhage
- Use of medications affecting tear secretion (like antihistamines or antidepressants) within the past 30 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 30 days
Participants undergo advanced eye examinations and imaging techniques to collect detailed ophthalmic data.
1 to 2 visits depending on eye examinations
Duration - Up to the study completion date
Participants are observed to monitor inflammation-related ophthalmopathy through collected imaging and clinical data.
Visits as needed for imaging and assessments
Trial Site Locations
Total: 1 location
1
Beijing Tongren Hospital
Beijing, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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