Actively Recruiting
Comparison of Cough Response Between Tegilidine and Sufentanil as Pre-induction Agents in General Anesthesia
Led by The First People's Hospital of Lianyungang · Updated on 2026-02-04
190
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the cough response in patients undergoing general anesthesia with planned tracheal intubation. This prospective, randomized, controlled, double-blind study compares the occurrence of cough two minutes after injection of either Tegilidine or Sufentanil. The study aims to grade coughing severity based on frequency and duration to better understand drug reactions during anesthesia induction. Patients are randomly assigned to one of two groups: an experimental group receiving Tegilidine at a dose of 20-50 µg/kg, or a control group receiving Sufentanil at 0.4 µg/kg. After arriving in the operating room, patients undergo routine monitoring including blood pressure, electrocardiogram, and oxygen saturation measurements. The assigned study drug is administered intravenously before anesthesia induction, and no other drugs are given prior to this. Coughing episodes are recorded and graded two minutes after drug administration. Participants will be monitored for blood pressure and heart rate at multiple time points before and after drug administration and intubation. The main outcome measured is the incidence of coughing two minutes after drug injection. Secondary outcomes include the severity grading of coughing, vital signs at specified intervals, and monitoring for any adverse reactions. The study involves elective surgery patients aged 18 to 65 years and includes careful observation during anesthesia induction and intubation periods.
CONDITIONS
Brief Title
Comparison of Cough Response Between Tegilidine and Sufentanil as Pre-induction Agents in General Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years with a body mass index (BMI) between 18 and 30 kg/m²
- ASA grade I to III
- Scheduled for elective surgery under general anesthesia with tracheal intubation
You will not qualify if you...
- Chronic cough lasting more than 8 weeks or asthma
- History of allergy to drugs used in the study
- Severe cardiovascular disease, intracranial lesions, eye lesions, or lung lesions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day during surgery
Participants receive an injection of either Tegilidine or Sufentanil before induction of general anesthesia. Coughing response and vital signs are monitored shortly after administration and during anesthesia induction.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
The Affiliated Lianyungang Hospital of Xuzhou Medical University
Lianyungang, Jiangsu, China
Actively Recruiting
Research Team
X
Xiaobao Zhang, Doctor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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