Comparison of Tegilerdine and Sufentanil to Reduce Cough During General Anesthesia Induction with Tracheal Intubation

What this Trial Is About

The trial investigates the occurrence of cough caused by opioid drugs during the induction of general anesthesia in patients planned for tracheal intubation. It compares two drugs, Tegilerdine and Sufentanil, to understand their effects on triggering coughs shortly after administration. This randomized, controlled study aims to provide insight into opioid-induced cough reactions in this surgical context. Participants are randomly assigned to receive either Tegilerdine at doses of 20-50 gkg or Sufentanil at doses of 0.2-0.4 gkg intravenously before anesthesia induction. Routine monitoring such as blood pressure, ECG, and oxygen saturation is conducted before drug administration. Cough episodes are recorded two minutes after the study drug injection, and anesthesia proceeds thereafter. The study uses a double-blind approach to ensure unbiased results. During the trial, participants are monitored for their cough response graded by frequency and duration. Blood pressure and heart rate are measured at multiple timepoints before and after drug injection and intubation. Adverse reactions are also recorded two minutes after drug administration. The primary outcome measures the incidence of cough 2 minutes after drug injection. The total participation timeframe includes the anesthesia induction period and immediate monitoring post-administration.

Effect of Tegileridine Versus Sufentanil as Analgesic Components on Opioid-Induced Cough During Anesthesia Induction