Effects of Sevoflurane General Anesthesia Versus Combined Spinal-Epidural Anesthesia on Ferroptosis and Protective Peptides in Kidney Transplant Recipients

What this Trial Is About

Renal transplantation is a key treatment for patients with end-stage renal disease, but ischemia-reperfusion injury can negatively impact graft function and long-term results. Ferroptosis, a type of cell death related to iron and oxidative stress, and mitochondrial peptides humanin and MOTS-c, which may protect cells, are involved in this process. This study evaluates how two different anesthetic methods affect these biomarkers in adult kidney transplant recipients. The study compares sevoflurane general anesthesia SGA and combined spinal-epidural anesthesia CSEA in patients undergoing kidney transplantation. Participants receive either sevoflurane anesthesia with standard protocols or combined spinal-epidural anesthesia with bupivacaine and morphine. Blood samples are collected immediately before anesthesia induction and before extubation to measure serum ferroptosis markers and mitochondrial peptides using biochemical tests. Participants will be monitored for early graft function and recovery outcomes including delayed graft function, serum creatinine levels, dialysis needs, urine output, and hospital stay length. The study tracks the relationship between biomarker levels and clinical outcomes during the perioperative and early postoperative periods. Overall, the study aims to improve understanding of anesthetic effects on transplant biology and support better anesthesia strategies for kidney recipients.

Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation