Effects of ultrasound-guided regional anesthesia in cardiac surgery: a systematic review and network meta-analysis.
Burhan Dost, Alessandro De Cassai, Eleonora Balzani...
https://pubmed.ncbi.nlm.nih.gov/36581838Actively Recruiting
Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID07452627
Comparison of Combined Transversus Thoracic Plane Block and Serratus Anterior Plane Block Versus Erector Spinae Plane Block for Managing Sternotomy Pain
Led by Uludag University · Updated on 2026-03-10
50
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating two regional anesthesia techniques to manage pain after cardiac surgery through median sternotomy. The study compares the combined Transversus Thoracic Plane Block (TTPB) and Serratus Anterior Plane Block (SAPB) versus the Erector Spinae Plane Block (ESPB). This prospective, randomized trial includes 50 adult patients aged 18 to 80 with ASA physical status I to III undergoing elective cardiac surgery. The goal is to find which technique better controls postoperative pain while reducing opioid use and related side effects. Participants are randomly assigned to receive either the TTPB+SAPB combination or the ESPB, both performed under ultrasound guidance after anesthesia induction and before surgery. During surgery, hemodynamic parameters are monitored, and rescue fentanyl is given if needed. Postoperatively in the ICU, all patients receive multimodal analgesia with intravenous paracetamol and tenoxicam. Pain is assessed using the Behavioral Pain Scale while intubated and the Visual Analog Scale after extubation, with rescue analgesics provided based on scores. Secondary measures include time to extubation, first mobilization, clinical transport, and patient and surgeon satisfaction. Throughout the study, researchers will evaluate pain intensity over 24 hours post-extubation, opioid consumption, recovery milestones, and safety outcomes like nausea requiring ondansetron. Patient and surgeon satisfaction are measured using a 5-point Likert scale. Data collection is blinded to minimize bias, and statistical analysis will compare outcomes between groups. The study aims to improve pain management protocols for cardiac surgery patients to support faster recovery and reduce complications.
CONDITIONS
Brief Title
Comparison of the Efficacy of Combined Transversus Thoracic Plane Block and Serratus Anterior Plane Block Versus Erector Spinae Plane Block in the Management of Sternotomy Pain
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients aged between 18 and 80 years
- Patients with ASA physical status I, II, or III
- Patients who provide written informed consent
- Patients scheduled for elective cardiac surgery via sternotomy
You will not qualify if you...
- Pregnancy or suspected pregnancy
- Body Mass Index (BMI) over 35 kg/m2
- History of allergy to local anesthetics or opioids
- Suspected coagulopathy or infection at the injection site
- Severe neurological, psychiatric, hepatic, or renal failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Day of surgery
Participants undergo general anesthesia followed by either a combination of Transversus Thoracic Plane Block and Serratus Anterior Plane Block or Erector Spinae Plane Block to manage sternotomy pain.
1 visit (in-person)
Post-operative Follow-up
Duration - Up to 48 hours post-surgery
Participants are monitored for pain intensity, analgesic use, extubation time, transport to ward, and satisfaction scores up to 24 to 48 hours after surgery.
Approximately 1 to 2 visits (in-person)
Trial Site Locations
Total: 1 location
1
Bursa Uludag University Hospital
Bursa, Nilüfer, Turkey (Türkiye), 16235
Actively Recruiting
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Comparison of continuous thoracic epidural analgesia with bilateral erector spinae plane block for perioperative pain management in cardiac surgery.
P S Nagaraja, S Ragavendran, Naveen G Singh...
https://pubmed.ncbi.nlm.nih.gov/30052229Comparison of the effects of transversus thoracic muscle plane block and pecto-intercostal fascial block on postoperative opioid consumption in patients undergoing open cardiac surgery: a prospective randomized study.
Mariana AbdElSayed Mansour, Hatem ElMoutaz Mahmoud, Dina Mahmoud Fakhry...
https://pubmed.ncbi.nlm.nih.gov/38341525