Actively Recruiting
Comparison of the Healing Properties on Corneal Cells of Growth Factor-Enriched Plasma and Autologous Serum From Aniridia Patients
Led by Fondation Ophtalmologique Adolphe de Rothschild · Updated on 2025-12-08
24
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the healing and anti-fibrotic effects of two blood-derived products, autologous serum and growth factor-rich plasma, on corneal cells from patients with aniridia compared to healthy controls. Aniridia causes abnormal corneal healing leading to scarring and clouding, and while autologous serum aids healing, it does not prevent fibrosis. This study aims to compare these two products' effects in the lab, examining their potential to reduce fibrosis markers. Participants include patients with aniridia and healthy controls. Blood samples are collected from all participants, with half used to prepare autologous serum and the other half to prepare growth factor-rich plasma for laboratory testing. Additionally, a conjunctival impression, a minimally invasive procedure collecting superficial eye surface cells, is performed at enrollment for biological analysis. Participants will have blood drawn and conjunctival samples collected at the start. Researchers will compare how the blood products affect corneal cell healing and fibrosis markers in vitro. The study monitors these laboratory outcomes to understand differences between aniridia patients and controls. The total participation involves these baseline collections and laboratory evaluations without further interventions or treatments.
CONDITIONS
Brief Title
Comparison of the Healing Properties on Corneal Cells of Groth Factor-enriched Plasma and Autologous Serum From Aniridia Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For patients with aniridia: diagnosed with aniridia
- Weight over 43 kilograms
- If treated with autologous serum, at least 8 weeks since last blood collection
- If blood donation was made, at least 8 weeks since last donation
- For controls: no signs of aniridia
- Weight over 43 kilograms
- Matched to a case for sex and age within 10 years
- No known diabetes
- If blood donation was made, at least 8 weeks since last donation
You will not qualify if you...
- Insufficient sample volume
- No conjunctival impression collected
- Positive for HBV, HCV, or HIV serology
- For aniridia cases, no genetic confirmation of aniridia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants provide blood samples and undergo conjunctival impression collection for biological analysis of ocular surface diseases.
1 visit (in-person)
Duration - Duration of laboratory analysis
Collected samples are used to compare the healing properties of autologous serum and growth factor-enriched plasma on corneal cells in a laboratory setting.
No participant visits required
Trial Site Locations
Total: 1 location
1
Hôpital Fondation A. de Rothschild
Paris, France, 75019
Actively Recruiting
Research Team
A
Amélie YAVCHITZ
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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