Actively Recruiting
Comparison of the Healing Properties on Corneal Cells of Groth Factor-enriched Plasma and Autologous Serum From Aniridia Patients
Led by Fondation Ophtalmologique Adolphe de Rothschild · Updated on 2025-12-08
24
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Keratopathy of patients with aniridia leads to epithelial scarring disorders and a progressive clouding of the cornea linked to this abnormal healing (fibrosis). Treatment with autologous serum is usually undertaken to promote epithelial healing. However, autologous serum does not prevent the formation of fibrosis, whereas growth factor-rich plasma appears to be associated with a reduction in the in vitro expression of fibrosis markers. This study seeks to compare the in vitro healing and anti-fibrotic properties of autologous serum and growth factor rich plasma from aniridia patients and healthy controls.
CONDITIONS
Official Title
Comparison of the Healing Properties on Corneal Cells of Groth Factor-enriched Plasma and Autologous Serum From Aniridia Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For patients with aniridia: diagnosed with aniridia
- Weigh more than 43 kg
- If treated with autologous serum, at least 8 weeks since last blood collection
- If blood donation was made, at least 8 weeks since last donation
- For controls: no clinical signs of aniridia
- Weigh more than 43 kg
- Matched to a patient by sex and age within 10 years
- No known diabetes
- At least 8 weeks since last blood donation
You will not qualify if you...
- Insufficient blood or sample volume
- No conjunctival impression collected
- Positive serology for HBV, HCV, or HIV
- Aniridia not genetically confirmed for patients
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hôpital Fondation A. de Rothschild
Paris, France, 75019
Actively Recruiting
Research Team
A
Amélie YAVCHITZ
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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