Study Comparing Healing Effects of Growth Factor-Enriched Plasma and Autologous Serum on Corneal Cells in Aniridia Patients and Healthy Controls

What this Trial Is About

Researchers are studying the healing and anti-fibrotic effects of two blood-derived products, autologous serum and growth factor-rich plasma, on corneal cells from patients with aniridia compared to healthy controls. Aniridia causes abnormal corneal healing leading to scarring and clouding, and while autologous serum aids healing, it does not prevent fibrosis. This study aims to compare these two products effects in the lab, examining their potential to reduce fibrosis markers. Participants include patients with aniridia and healthy controls. Blood samples are collected from all participants, with half used to prepare autologous serum and the other half to prepare growth factor-rich plasma for laboratory testing. Additionally, a conjunctival impression, a minimally invasive procedure collecting superficial eye surface cells, is performed at enrollment for biological analysis. Participants will have blood drawn and conjunctival samples collected at the start. Researchers will compare how the blood products affect corneal cell healing and fibrosis markers in vitro. The study monitors these laboratory outcomes to understand differences between aniridia patients and controls. The total participation involves these baseline collections and laboratory evaluations without further interventions or treatments.

Comparison of the Healing Properties on Corneal Cells of Groth Factor-enriched Plasma and Autologous Serum From Aniridia Patients