Actively Recruiting
Puncture to Repigment: A Comparative Analysis of Needling vs. Microneedling Along with NBUVB in Treatment of Non-Segmental Vitiligo
Led by Khyber Teaching Hospital · Updated on 2025-09-02
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of needling versus microneedling, both followed by narrowband UVB (NBUVB) therapy, in treating patients with localized stable non-segmental vitiligo. This randomized controlled trial focuses on comparing how well these two procedures help achieve repigmentation in the affected skin. The study includes patients aged 15 to 60 years who have had vitiligo for more than one year. Participants will be randomly assigned to one of two groups. One group will receive needling using a sterile 30G (4mm) needle to implant melanocytes from nearby pigmented skin into depigmented areas, while the other group will undergo microneedling with a Dermapen device that creates controlled micro-injuries to encourage repigmentation. Both procedures are performed once every four weeks for six sessions, each followed by NBUVB phototherapy. During the 12-week study period, researchers will assess the percentage of skin repigmentation using digital planimetry and standardized photography. They will also monitor any side effects such as redness, post-inflammatory darkening, infection, and scarring. The study aims to provide detailed information about treatment results and safety by the end of the trial period.
CONDITIONS
Brief Title
Comparison of Needling and Microneedling Plus Phototherapy in Localized Vitiligo Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Both male and female
- Age 15-60 years
- Patients having vitiligo for more than 1 year
You will not qualify if you...
- Patients with tendency of keloid formation or hypertrophic scarring
- Patients with any bleeding disorder, coagulation defect or using anti platelets
- Any local infection at the treatment site
- Patients who had received systemic therapy in last 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants receive either needling or microneedling procedures followed by NBUVB phototherapy to promote repigmentation in localized vitiligo lesions.
6 visits, once every 4 weeks
Trial Site Locations
Total: 1 location
1
Khyber Teaching Hospital
Peshawar, Khyber Pakhtunkhwa, Pakistan, 25000
Actively Recruiting
Research Team
H
Huma Gul Doctor, MBBS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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