Study of Tolerance and Adherence to Oral Antibiotics in Adults with Bone and Joint Infections

What this Trial Is About

Researchers are studying bone and joint infections BJI, which are bacterial infections that can occur after surgery or on their own. Though these infections are rarely fatal in the short term, they can cause significant health problems, reduce quality of life, and increase medical costs. Treatment typically involves antibiotics, often combined with surgery, but the long duration and side effects of antibiotic therapy can make it difficult for patients to stick to their treatment plan. This observational study focuses on patients with BJI who have had surgery and are taking at least one oral antibiotic afterward. The study will measure how well patients adhere to their antibiotic treatment and how well they tolerate it. Adherence will be assessed at 6 weeks and 3 months after surgery using electronic pill dispensers and questionnaires. Tolerance to antibiotics will be evaluated at baseline, 6 weeks, and 3 months post-surgery through patient questionnaires and telephone interviews. Participants will be monitored through questionnaires and electronic devices that track medication use. Data on antibiotic tolerance will be collected at several points, including before and after surgery. Researchers will review the percentage of doses taken at 6 weeks and 3 months as the main outcomes. The study involves telephone follow-ups and data transfers by nursing staff, with total participation lasting at least 3 months after surgery.

Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections (OTABIO)