Complications of Implantation Procedures

This research investigates alveolar ridge preservation after tooth extraction by examining different methods to support bone regeneration. It focuses on the use of autologous tooth root slices, bone graft materials, collagen plugs, and vitamin D3 to improve healing and bone formation in the extraction site. Advanced 2D and 3D imaging technologies are used to monitor bone regeneration without invasive biopsies. The study evaluates if combining these biological materials and treatments can increase bone formation rates and stabilize the wound more effectively than traditional methods. Participants are randomly assigned to one of four groups receiving different combinations of treatments: bone graft with collagen plug alone; bone graft, collagen plug, and local vitamin D3; bone graft, collagen plug, and autologous tooth root slices; or bone graft, collagen plug, vitamin D3, and autologous tooth root slices. The autologous tooth root slices are placed over the extraction socket to seal it and help protect bone graft materials, while the skin flap is surgically raised to cover and stabilize the tooth root cover. This approach aims to reduce contamination and promote faster healing. Throughout the study, participants undergo imaging assessments including 3D computed tomography, periapical X-rays, and intraoral scans at the start and between weeks 12 to 16 after extraction. Implant stability is also measured between weeks 16 and 24. These evaluations help researchers observe bone regeneration progress and wound healing. The total participant involvement spans from initial tooth extraction through follow-up periods to assess treatment effects and implant stability.

Researchers are evaluating the medium-term performance and safety of two types of dental implants: the Straumann PURE 2-piece Ceramic Implant made of zirconia and the Straumann Bone Level Implant made of titanium. The study aims to compare these implants using a fully digital workflow to understand their biological and technical complications, patient satisfaction, and aesthetic outcomes over a five-year period. Titanium implants have a metallic color that often requires deeper placement, which can complicate hygiene, while zirconia implants offer a color closer to natural teeth. Participants will receive either the zirconia ceramic implant or the standard titanium implant placed in healed extraction sites in the premolar-to-premolar area of the upper or lower jaw for single tooth replacement. After implant placement, prosthetic loading with a definitive crown will occur following a six-month healing period. Both groups undergo routine treatment, with the only difference being the implant material. The surgical approach follows guidelines for healed extraction sites approximately 16 weeks after tooth loss. During the five-year follow-up after implant loading, participants will attend scheduled visits where researchers will measure bone level changes, implant survival rates, and complication-free survival. Patient satisfaction and oral health impact will also be assessed using questionnaires. Data will be collected and analyzed to compare long-term implant performance and safety. Participation involves regular evaluations to monitor outcomes and ensure safety throughout the study duration.

Researchers are evaluating the clinical performance of a new generation of customized CAD/CAM pre-fabricated root-analog dental implants in patients who have experienced tooth loss. This observational prospective cohort study aims to determine if these drilling-free implants are safe, effective, and clinically viable over a 36-month period and whether they provide better post-operative outcomes compared to traditional implant methods. The study is conducted by the University of Sao Paulo. Participants in this study have received personalized dental implants using the iDENTICAL Dental Implant System immediately after tooth extraction during a previous interventional phase. This study follows a single group of twelve patients over 36 months, monitoring the implants at 12, 24, and 36 months after prosthesis installation. The focus is on assessing implant survival, peri-implant tissue health, post-operative comfort, bone preservation, and tissue integration. During the study, participants will undergo clinical and radiographic examinations at the specified time points to measure radiographic success, changes in peri-implant soft tissues, prosthetic outcomes, and other peri-implant clinical parameters. The study requires availability for follow-up visits throughout the 36-month observation period. Safety and efficacy data will be collected to understand the long-term outcomes of these customized dental implants.

Researchers are studying pacing-induced cardiomyopathy (PICM), a condition where chronic right ventricular pacing harms left ventricular function. This observational study focuses on ECG and echocardiogram parameters, including strain, as well as genetic factors, to identify patients at high risk of developing PICM after pacemaker implantation. The goal is to better predict who might develop PICM and understand its clinical impact over time. Participants will have ECG and echocardiogram tests before and after pacemaker implantation to assess key measurements such as QRS duration and mechanical strain. Genetic factors may also be evaluated to improve prediction of PICM occurrence. This study involves long-term follow-up to monitor the condition and its outcomes. During the study, participants will be clinically followed for up to 5 years to observe heart failure diagnosis and treatment. Researchers will also track atrial and ventricular arrhythmias, hospital admissions for heart failure, and overall mortality. The study does not involve treatment interventions but focuses on monitoring and data collection to understand PICM and its clinical outcomes.

Researchers are evaluating whether the Xperience™ surgical irrigation solution is more effective than a standard dilute povidone-iodine solution in reducing surgical site infections following implant-based breast reconstruction in women aged 18 and older. The study also aims to compare the safety and overall surgical outcomes between Xperience™ and povidone-iodine. This clinical trial is a randomized controlled trial sponsored by the University of North Carolina, Chapel Hill. Participants will be randomly assigned to receive either the Xperience™ solution or the dilute povidone-iodine solution during their bilateral implant-based breast reconstruction surgery. Xperience™ will be applied twice during the procedure, soaking both the mastectomy pockets and implants with specific volumes and dwell times before insertion. The povidone-iodine solution will be applied similarly. Surgical site closure will follow standard procedures for all participants. During the study, participants will have regular post-operative check-ups to monitor for infections and other complications. Researchers will collect data on the rates of surgical site infections, premature implant removal due to infection, and non-infectious post-surgical complications within 90 days after implant placement. The study will monitor safety and overall outcomes through these evaluations, with participation lasting through this 90-day post-surgery period.

Researchers are evaluating the effect of Horizontal Platelet Rich Fibrin (H-PRF) on the stability and bone levels of dental implants in adults. This randomized controlled clinical trial focuses on patients receiving dental implants in the upper or lower jaws at Dublin Dental University Hospital. H-PRF is a biologic material derived from patients' blood that may encourage bone growth and implant integration, and this study aims to compare implants placed with and without H-PRF to assess its potential benefits. Participants will be randomly assigned to one of two groups: one where implants are coated with H-PRF and another where implants are placed without H-PRF. The H-PRF is prepared by drawing blood from patients, then processing it in a horizontal centrifuge to create a clot used during implant placement. Implants will be placed using standard surgical protocols, and the procedure will be identical for both groups aside from the use of H-PRF. During the study, participants will have implant stability and bone levels measured at implant placement, three months later, and at the time of implant restoration (around 4 to 5 months). Pain levels will be recorded at various points after surgery, and the occurrence of implant loss, fracture, or infection will be monitored. Patients will also maintain symptom diaries and attend scheduled study visits. The study will last several months, with careful monitoring to evaluate the impact of H-PRF on dental implant success.

Researchers are investigating the use of ABM/P-15 bone graft compared to traditional bone graft in patients undergoing surgery for Adult Spinal Deformity (ASD). This study aims to improve clinical outcomes by promoting faster bone healing, reducing the need for additional surgeries, minimizing complications, and improving health-related quality of life. The trial is a prospective, randomized, controlled clinical study conducted at a specialized spine unit. Participants are randomly assigned to receive either the ABM/P-15 bone graft, which is a device combining anorganic bovine bone mineral with a synthetic peptide to enhance bone growth, or a standard bone graft made from locally harvested bone mixed with morselized allogenic femoral head. Both graft types are used during posterior spinal instrumentation and fusion surgery, with anterior support added as needed. The ABM/P-15 bone graft is placed on the spine structures and contained by the surrounding muscle. The study includes preoperative planning, surgery, and follow-up evaluations up to two years. Participants complete questionnaires before surgery and at 3 months, 1 year, and 2 years after surgery. They undergo X-rays at multiple time points and a CT scan one year after surgery to assess bone fusion and detect pseudarthrosis. Researchers track revision surgeries, adverse events, and cost-effectiveness during the study. Data on surgical details, complications, medication use, and rehabilitation are collected from medical records. The total participation lasts about two years, allowing for detailed assessment of outcomes and safety.

Researchers are evaluating the accuracy and long-term outcomes of dental implants placed using two types of static surgical guides: 3D-printed and milled. The study focuses on patients needing dental implant rehabilitation and aims to determine if there are differences in implant placement precision and clinical success between these guide fabrication methods. This randomized controlled trial also considers peri-implant health, implant survival, and patient satisfaction as important factors. Participants will be randomly assigned to receive implant surgery guided by either a 3D-printed or a milled surgical guide. Both guides are designed with sleeves to ensure precise implant placement based on digital planning. The surgery is performed under local anesthesia, with follow-ups scheduled for suture removal and healing checks. After three months, digital impressions will be taken to assess implant position accuracy and to fabricate final prostheses, which will be placed about one month later. Follow-up visits at six and twelve months post-prosthesis placement will monitor implant stability and overall success. During the study, participants undergo thorough dental examinations including radiographs, photographs, and intraoral scans. Researchers will measure implant position accuracy by comparing planned and final implant locations and assess outcomes such as probing depth, bleeding, implant survival, and patient-reported pain and satisfaction. Medication use and healing progress will be recorded, and all implant treatments and monitoring are closely supervised for one year. The study includes careful data protection and offers implant-related components at no cost, with some participant costs for surgery and prosthetic parts.

The trial investigates risk factors and outcomes for patients who require acute surgical care, focusing on three specific conditions: acute pancreatitis, gastrointestinal bleeding, and perforated ulcer. Researchers aim to improve risk assessment tools and identify factors linked to complications or death, especially considering frailty, comorbidity, age, and gender. The study is observational and retrospective, analyzing patients admitted to Skåne University Hospital from 2009 to 2019. Patients are grouped based on the severity of acute pancreatitis (mild, moderate, severe), presence of gastrointestinal bleeding, perforated ulcer, age (above or below 70 years), use of prothrombotic medications, frailty score, and whether they needed reintervention. Treatments vary according to clinical decisions made during care, and the study observes these variations without assigning interventions. Participants' medical records from the hospital are reviewed to gather data on mortality, reintervention, and recurrent disease over five years. Additional measures include length of hospital stays, number of interventions, and complications. The study's results aim to inform future prospective studies on preventative care and treatment options. Participation involves no active treatments but detailed record analysis and long-term outcome monitoring.

Researchers are conducting a study called Acutelines, a large data and biobank project at the University Medical Center Groningen in the Netherlands. It focuses on patients with a wide range of acute medical conditions who present to the Emergency Department. The goal is to improve how acute diseases are recognized and treated, understand their outcomes, and support personalized medicine by collecting detailed clinical data, imaging, and biomaterials over time. Participants have their medical information, including demographics, health status, medical history, vital signs, diagnostic tests, and treatments, systematically collected. Biomaterials such as blood, urine, feces, and hair are gathered from patients who meet certain severity criteria. Data collection occurs during hospital admission, including continuous monitoring, and continues with follow-ups at 3 months, 1 year, 2 years, and 5 years after the initial emergency visit. Throughout the study, various assessments are performed, such as quality of life, physical functioning, mental health, symptoms, and hospital length of stay. Researchers collect data on mortality and other health outcomes for up to 50 years. The study uses digital tools to automate data capture and integrates information from multiple healthcare sources. Participants will be monitored closely during hospitalization and at scheduled intervals afterward to help improve understanding and treatment of acute diseases.