Actively Recruiting
Using 2D/3D Imaging to Analyze Bone Regeneration During Alveolar Ridge Preservation Surgery with Autologous Tooth Root, Bone Grafts, and Vitamin D3 Treatment
Led by Chang Gung Memorial Hospital · Updated on 2024-12-02
48
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates alveolar ridge preservation after tooth extraction by examining different methods to support bone regeneration. It focuses on the use of autologous tooth root slices, bone graft materials, collagen plugs, and vitamin D3 to improve healing and bone formation in the extraction site. Advanced 2D and 3D imaging technologies are used to monitor bone regeneration without invasive biopsies. The study evaluates if combining these biological materials and treatments can increase bone formation rates and stabilize the wound more effectively than traditional methods. Participants are randomly assigned to one of four groups receiving different combinations of treatments: bone graft with collagen plug alone; bone graft, collagen plug, and local vitamin D3; bone graft, collagen plug, and autologous tooth root slices; or bone graft, collagen plug, vitamin D3, and autologous tooth root slices. The autologous tooth root slices are placed over the extraction socket to seal it and help protect bone graft materials, while the skin flap is surgically raised to cover and stabilize the tooth root cover. This approach aims to reduce contamination and promote faster healing. Throughout the study, participants undergo imaging assessments including 3D computed tomography, periapical X-rays, and intraoral scans at the start and between weeks 12 to 16 after extraction. Implant stability is also measured between weeks 16 and 24. These evaluations help researchers observe bone regeneration progress and wound healing. The total participant involvement spans from initial tooth extraction through follow-up periods to assess treatment effects and implant stability.
CONDITIONS
Brief Title
2D/3D Imaging to Analyze the Regeneration Rate of Autologous Bone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing to sign written subject consent
- Tooth extraction socket located in upper or lower jaw
- Extraction socket area planned for future artificial dental implants
- No systemic diseases such as hypertension, osteoporosis, bone-related diseases, kidney disease, thyroid or parathyroid diseases
You will not qualify if you...
- Patients with weakened healing abilities such as cancer, diabetes, bone infection, tuberculosis, anemia, immune deficiencies, cellulitis, acute periodontal cyst, severe cusp disease (cyst size >2mm2), or dental and jaw lesions
- Women who are pregnant or breastfeeding
- Heavy smokers or betel nut chewers who smoke more than one pack of cigarettes per day
- Severe bone defects requiring other bone regeneration surgeries (GBR) that do not provide enough volume for implants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 12 to 16 weeks
Participants receive alveolar ridge preservation surgery involving placement of bone graft, collagen plug, and may receive autologous tooth root slices and/or local administration of Vit.D3 depending on their assigned group.
1 surgery visit and follow-up visits during treatment period
Duration - 4 to 12 weeks after treatment
Participants undergo imaging and stability assessments to monitor bone regeneration and implant stability after treatment.
1 to 2 visits including 3D computed tomography, periapical X-ray, intraoral scanning, and RFA measurements
Trial Site Locations
Total: 1 location
1
Chang Gung Memorial Hospital
Taoyuan, Taiwan
Actively Recruiting
Research Team
H
Hsiang Hsi Hong
W
Wen H Chi
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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