Patellofemoral Pain Syndrome

Researchers are evaluating post-operative management approaches after a modified Lapidus arthrodesis surgery for hallux valgus, with or without additional surgeries such as Akin or Weil/Hohmann procedures. The study aims to compare the effectiveness and safety of immediate full weight-bearing versus partial weight-bearing (10-15 kg) during rehabilitation. This randomized controlled trial explores a new rehabilitation method following foot surgery to improve recovery. Participants will be randomly assigned to one of two groups after surgery: one group will follow partial weight-bearing with a specialized VACOPASO shoe and use crutches along with antithrombotic medication for 6 weeks, while the other group will have immediate complete weight-bearing with the same shoe and medication for the same period. The surgical operation follows standard clinical practices for hallux valgus correction. During the study, healing progress will be monitored through standard X-rays at 6, 12, and 24 weeks to check bone healing, hardware fixation, and fracture alignment. Pain will be measured using a Visual Analogue Scale at the day of surgery and at follow-up visits. Quality of life and functional recovery will be assessed through established foot and ankle scoring systems at multiple time points. The main outcome is the subjective functional recovery measured by the Olerud and Molander Ankle Score at 6 weeks post-surgery.

Researchers are studying tendinopathy, a common condition causing chronic tendon pain and degeneration, to understand the differences between normal and symptomatic tendon states using Shear Wave Elastography (SWE). This observational study aims to compare the viscoelastic properties of tendons in people with and without symptoms and to evaluate tendon healing after standard treatments. The study includes moderate-to-severe chronic tendinopathy cases lasting more than six months. Participants undergo ultrasound imaging using SWE to examine tendons such as the Achilles, patellar, quadriceps, epicondylar, and rotator cuff. The study includes two groups: asymptomatic volunteers with lower extremity pain but no tendon involvement, and symptomatic volunteers diagnosed with tendinopathy. Some participants may have repeated imaging for up to one year to monitor tendon healing following standard care. During the study, participants will have tendon imaging sessions lasting about 20 minutes each. The research team will measure tendon properties at baseline and track changes in tendon healing over 3, 6, and 12 months. They will also assess functional scores related to Achilles and patellar tendons and foot and ankle disability at multiple timepoints. This detailed follow-up helps understand tendon function and recovery over time.

Researchers are evaluating the effects of different exercise training methods on muscle structure and the prevention of Patellofemoral Pain Syndrome and Anterior Cruciate Ligament (ACL) injuries in sportsmen aged 15 to 35 who participate in level 1 sports such as martial arts, basketball, futsal, and soccer. This clinical trial compares low-load blood flow restriction training (LL-BFRt), a sham version of LL-BFRt, and high-load eccentric training (HL-Et) to see which method better improves muscle morphology and reduces injury risk. Participants will be randomly assigned to one of three groups: LL-BFRt, sham LL-BFRt, or HL-Et. The LL-BFRt group will perform eccentric exercises like stairs, single leg squats, and single leg deadlifts at 30% of their maximum repetition and with 70% arterial occlusion pressure applied by cuffs. The sham LL-BFRt group will do the same exercises at 30% maximum repetition but with only 10% arterial occlusion pressure. The HL-Et group will perform the exercises at 70% maximum repetition without blood flow restriction. Both treatments are guided by a physical therapist. Throughout the study, researchers will measure muscle cross-sectional area, fiber angle of the vastus medial obliques, and patella position after 8 weeks. They will also monitor the incidence of Patellofemoral Pain Syndrome and ACL injuries over one year. Participants are expected to maintain their assigned exercise regimen and provide informed consent. The study aims to understand which training method offers better muscle improvements and injury prevention in active sports participants.

Researchers are evaluating the effect of a student-led multimodal prehabilitation service called BoneFit for people preparing for total hip or knee replacement surgery. The study aims to improve physical and mental health, quality of life, and reduce hospital stay length, complications, and readmission rates for patients undergoing orthopedic surgery in the Hull region. This pilot feasibility study will compare BoneFit to usual care, as no prehabilitation service is currently offered locally. Participants in the BoneFit intervention group will receive a personalized care plan that includes exercise, nutrition, and psychological support tailored to their needs during the 8 weeks before surgery. A control group will receive usual care without intervention. The groups will be compared to assess the impact of the prehabilitation service. During the study, participants will undergo baseline tests and will be invited to repeat these assessments 3 months after surgery. Researchers will monitor recruitment, attendance, and acceptability over several years. They will also measure physical fitness, hospital length of stay, readmission rates, overall quality of life, and specific pain and function related to the knee or hip. The study will last up to 3 years, with ongoing follow-up assessments to evaluate outcomes.

This observational study is focused on collecting data about the performance of CERAMENT BONE VOID FILLER, a synthetic biphasic bone graft substitute, when used in typical medical practice for orthopedic disorders. The study is sponsored by BONESUPPORT AB and aims to gather information on device performance and patient outcomes to understand its use in real-world settings. Participants will receive CERAMENT BVF as part of their treatment at approved healthcare centers following the product's instructions for use. Data collection includes monitoring unexpected device performance, complaints, adverse events, and serious adverse events during surgery and continuing up to 18 months after treatment. Radiological assessments, pain scores, and quality of life evaluations will be conducted at intervals throughout the study. During the study, participants will undergo scheduled reviews at 6, 12, and 18 months to assess device-related outcomes and healing progress using imaging and questionnaires. Researchers will track safety events and gather patient-reported outcomes such as pain levels and quality of life. Participation involves following up with healthcare providers over this period to provide ongoing data for comprehensive evaluation of the device's performance.

This research evaluates the clinical and radiological outcomes in patients who have undergone total ankle replacement for advanced ankle osteoarthritis. The study aims to assess results achieved by surgeons who did not originally design the implant, addressing potential bias seen in prior studies where designers performed the surgeries. The goal is to compare these outcomes with those of ankle arthrodesis, considering improvements in surgical techniques and ankle biomechanics knowledge. Participants in the study have received total ankle arthroplasty using a third-generation ankle replacement device. Clinical assessments are performed before and after surgery, with a minimum follow-up of 12 months. These include the American Orthopedic Foot and Ankle (AOFAS) score, the Foot Function Index, and the visual analogue scale (VAS) for pain. Weightbearing ankle X-rays are taken before surgery and at the final follow-up, with independent review by an orthopedic surgeon. During the study, participants complete scheduled follow-up evaluations, questionnaires, and radiographic exams. Researchers measure implant survivorship over 10 years along with various ankle joint angles and functional scores. The study monitors clinical progress, radiological changes, and foot function to evaluate long-term outcomes of the ankle replacement procedure.

This research aims to compare two surgical techniques for treating iliopsoas tendinopathy caused by impingement between the iliopsoas tendon and the prosthetic cup in patients who have undergone total hip replacement. The study evaluates clinical improvement using the Oxford Hip Score measured at baseline, 2 months, and over 12 months after surgery. It is a randomized, single-blind, comparative trial conducted at a single center. Participants will undergo endoscopic tenotomy surgery of the iliopsoas tendon, performed either at the lesser trochanter or at the acetabular notch. Patients are randomly assigned to one of these two groups by drawing lots. The surgery is carried out under general anesthesia with standardized multimodal pain management, and all other surgical approaches and postoperative care remain consistent between groups. During the study, patients will be assessed with the Oxford Hip Score before surgery, at 2 months, and at more than 12 months after the procedure to measure clinical improvement. The study monitors patient outcomes and recovery following the surgery. Participation involves preoperative consultation, surgery, and follow-up assessments over at least one year to evaluate the treatment effect.

The trial investigates the comparative effects of perturbation training and functional stabilization training on pain, balance, and performance in athletes with patellofemoral pain syndrome (PFPS). PFPS is a common cause of anterior knee pain caused by muscle imbalances around the knee cap, affecting young athletes aged 15 to 30. The study focuses on how these training programs impact knee pain, muscle control, balance, and athletic performance in this group. Participants are divided into two groups: one will receive functional stabilization exercises combined with traditional treatment, while the other will undergo perturbation training. The functional stabilization group will perform exercises such as lateral and ventral bridges, hip abduction and rotation, pelvic drops, single-leg deadlifts and squats, and knee flexion and extension over an 8-week period. The perturbation group will engage in balance activities like foam balance, tilt board, and roller board exercises. Both groups will begin with a 30-minute education session and undergo pre- and post-intervention assessments. During the study, participants will be evaluated using multiple tools including a numerical pain rating scale, horizontal and vertical jump tests, 40-yard sprint test, lower extremity functional scale, and star excursion balance test over 10 months. Data will be analyzed to assess changes in pain, balance, and performance. The study uses randomized allocation and single masking to compare the two training methods and monitor their effects on athletes with PFPS.

Researchers are evaluating the effectiveness of an electrical muscle stimulation (EMS) device in patients with patellofemoral pain syndrome, also known as anterior knee pain. This condition is common among young athletes and is believed to involve weakness in the vastus medialis obliquus muscle. The study aims to determine if adding EMS to standard physical therapy (PT) can speed recovery and improve outcomes compared to PT alone. This is a phase 3 randomized study with a larger sample size than previous research to better assess the device's impact. Participants are assigned to one of two groups: one receiving both EMS and physical therapy, and the other receiving only physical therapy. The EMS device used is the Flex MT Plus, an FDA-approved neuromuscular stimulator applied to the vastus medialis obliquus muscle for 20 minutes, three times daily, five days a week, over 12 weeks at 40 Hz with specific pulse settings. Physical therapy consists of standard exercises for strengthening. During the study, participants will be followed for up to 12 months after enrollment, with a total study duration of two years. Researchers will assess outcomes including the Kujala patellofemoral score, visual analog pain scale during daily activities, and isometric knee strength. Secondary outcomes include the rate and timing of return to sports activities. Safety and progress will be monitored regularly throughout the study.

Researchers are evaluating and comparing the effects of two physiotherapy techniques, Maitland mobilizations and Mulligan Mobilization With Movement (MWM), on adults aged 18 to 40 years who have Patellofemoral Pain Syndrome. This randomized controlled trial aims to study differences in pain levels, knee range of motion, and lower extremity function in this patient group. Participants are randomly assigned to one of two treatment groups: Group A receives Mulligan Mobilization With Movement, involving medial patellar glide and tibial internal rotation techniques, while Group B receives Maitland patellar mobilizations with four specific mobilization techniques. Both groups perform the same set of therapeutic exercises after mobilization. Treatments are given in three sessions per week on alternate days over a two-week period. Participants attend assessments at the start and end of the two-week treatment period. Pain is measured using the Numeric Pain Rating Scale (NPRS), knee range of motion with goniometry, and function with the Lower Extremity Function Scale (LEFS). Data from before and after treatment will be compared to evaluate outcomes. The total duration of participation for each person is about two weeks.