Shoulder Impingement Syndrome

This research aims to evaluate the effects of two different physical therapy techniques, Neuromuscular Reeducation (NMR) and Post Facilitation Stretch (PFS), on Upper Cross Syndrome among IT professionals. The study involves adults aged 20 to 40 years who have been diagnosed with this condition and have experienced pain for at least two months. The goal is to compare these techniques for improving symptoms related to this syndrome. Participants are divided into two groups: one group receives the NMR technique, which involves deep pressure along the muscles from origin to insertion combined with active movement and rest periods. The other group receives the PFS technique, which consists of isometric muscle contractions followed by rapid stretching and relaxation. Both groups also perform strengthening exercises for weak muscles as part of their treatment. The treatments are applied specifically to tight muscles including the levator scapulae, upper trapezius, and pectoralis major. Before treatment, baseline measurements are taken for neck range of motion (ROM), pain intensity using the Numeric Pain Rating Scale (NPRS), and neck disability index. After two weeks of treatment, these measures are repeated to assess changes. Participants undergo assessments at the start and after two weeks to compare improvements. The study monitors neck function, pain levels, and disability related to the syndrome throughout the treatment period.

Calcific tendinitis of the shoulder is a common condition involving calcium deposits in the rotator cuff tendons, often causing pain and functional issues. While many classification systems exist, they do not directly guide treatment or prognosis. This study aims to create a new, practical classification based on MRI localization of the deposits, and to explore how this classification relates to the treatments patients receive. The study reviews MRI scans and clinical records from patients treated for calcific tendinitis between 2004 and 2025. Patients are categorized into five groups according to where the calcium deposits are located on MRI: outside the tendon, inside near the joint side, inside near the bursal side, completely within the tendon, or extending into the bone. Treatments include conservative non-surgical methods like pain relief and rest, or surgical interventions such as removal of the deposit and tendon repair techniques. Participants' medical records, operative notes, and treatment details are examined to see how treatment relates to the new classification. The main outcome measured is the change in shoulder function and pain scores from before treatment to 12 months after surgery. This observational study involves reviewing existing patient data to understand the link between deposit location and treatment outcomes over time.

Partial-thickness rotator cuff tear is a common shoulder condition where tears involve 50% or less of the tendon thickness. This trial evaluates the safety and effectiveness of an investigational treatment called TPX-115, which consists of allogeneic fibroblasts injected into the tendon. The study aims to improve tendon repair beyond standard conservative treatments by measuring shoulder function and pain scores over time. Participants are randomly assigned to receive either TPX-115 or a placebo injection guided by ultrasound directly into the tendon. The study is double-blinded, meaning neither participants nor researchers know which treatment is given. Assessments occur at 4, 12, 24, and 52 weeks after injection, with structural evaluations using MRI at 24 and 52 weeks to monitor tendon changes. During the study, participants will complete various shoulder function tests including the Constant Score, pain assessments using Visual Analogue Scale, and other shoulder-specific questionnaires. Range of motion and MRI scans will also be performed to observe physical and structural changes. The primary outcome is the change in Constant Score at 24 weeks, with ongoing safety and efficacy monitoring through one year of follow-up.

This research aims to evaluate the therapeutic effectiveness of using an acellular dermal matrix derived from human skin combined with autologous orthobiologics for patients with large to massive rotator cuff tears. The study focuses on patients with tears involving the supraspinatus and infraspinatus tendons, addressing a significant surgical challenge. The trial is sponsored by Istituto Ortopedico Rizzoli and involves a randomized, double-blind design to compare treatment methods. Participants will be randomly assigned to one of two groups: one group will receive a suture-bridge surgical repair augmented with the acellular dermal matrix alone, while the other group will receive the same surgical technique combined with orthobiologic treatments, including humeral bone marrow concentrate and subacromial bursa tissue. The orthobiologics are harvested and prepared during surgery using an automatic concentrating system. Both treatments use standard arthroscopic procedures with dedicated sutures and anchors. Throughout the study, participants will undergo pre-operative magnetic resonance imaging and complete outcome assessments. Researchers will monitor the re-tear rate of the rotator cuff at 12 months after surgery as the primary outcome. Secondary outcomes include cell yield and subacromial bursa assessments at baseline. The trial requires participants to be able to understand and complete outcome scores and involves follow-up to evaluate the healing and effectiveness of the treatments over time.

Researchers are investigating the role of acupuncture in managing pain and improving outcomes after total knee replacement surgery (TKA) for patients with primary osteoarthritis. This study aims to assess whether acupuncture can help control acute pain, prevent chronic pain, improve joint function, and increase patient satisfaction. The research also examines how acupuncture influences inflammation by measuring specific biomarkers, which may relate to recovery and long-term joint stiffness. Participants will receive standard anesthesiology care including sedation, regional nerve blocks, and pain medications. They will be randomly assigned to either a standard treatment group or an acupuncture group, which receives additional acupuncture and auriculotherapy sessions before and after surgery. The acupuncture treatment targets specific body and ear points over multiple sessions during the first three days post-surgery. Throughout the study, participants will be monitored regularly for pain levels, medication use, vital signs, joint mobility, and rehabilitation progress. Blood samples will be taken before surgery and at set intervals afterward to measure inflammation markers. Patient-reported outcomes and satisfaction will be collected up to one year post-surgery. Evaluations will be done in person or by phone if necessary, with the entire follow-up extending through one year after the operation.

Researchers are comparing three types of nerve blocks used for managing pain after shoulder arthroscopic surgeries. The study focuses on anterior glenoid nerve block, pericapsular nerve group (PENG) block, and interscalene brachial plexus (ISB) block. These blocks help reduce postoperative pain, improve patient comfort, speed up rehabilitation, and potentially shorten hospital stays. ISB blocks are well known as the standard method, while the PENG block is a newer technique that may provide pain relief with fewer side effects and quicker movement recovery. Participants will be randomly assigned to receive one of the three nerve blocks: the interscalene brachial plexus block, the anterior glenoid nerve block, or the pericapsular nerve group (PENG) block. All blocks are applied using ultrasound guidance during shoulder arthroscopic surgery. The study is double-blinded, meaning neither patients nor doctors know which block is given to ensure unbiased results. During the study, researchers will monitor the time until patients need their first rescue pain medication within 24 hours after surgery. They will also track total opioid use, pain levels, hospital stay duration, time to freely move the operated shoulder, and patient satisfaction. These measures help assess each block's effectiveness and safety. The entire study includes follow-up up to one week after surgery to observe recovery progress and potential complications.

This research aims to analyze patients who come to the emergency department with anterior shoulder dislocation. The study focuses on documenting patient demographics, injury causes, orthopedic classifications, treatment methods, pain scores before and after procedures, and the time spent in the emergency department. The goal is to see if any current treatment approach leads to better emergency outcomes for these patients. Patients will be observed as they receive one of four types of analgesic treatments chosen by their doctors: ketamine, interscalene nerve block, suprascapular nerve block, or intraarticular lidocaine injection. The study will not change how treatments are given but will compare these groups based on pain management, time needed for shoulder reduction, patient comfort, and hospital stay length. Participants will be followed during their emergency department visit to collect data on treatments, pain levels, and outcomes such as discharge or admission to a ward. Researchers will review these details within 24 hours, focusing on the shoulder reduction process. The study includes monitoring patient outcomes related to their treatment and emergency stay duration without interfering in medical care.

This research aims to explore the use of shock wave therapy combined with conventional rehabilitation training for patients diagnosed with rotator cuff tears who choose conservative treatment. The study is a single-center clinical trial enrolling about 22 patients from the Department of Sports Medicine and Rehabilitation at Beijing Third Hospital. It seeks to provide new treatment ideas to promote tendon healing, improve shoulder function, and help patients return to daily activities and exercise faster. Participants will receive either shock wave therapy along with functional exercise seven times a week or conventional conservative treatment paired with functional exercise. The study compares these two approaches to evaluate their clinical effects on rotator cuff tear recovery. This approach hopes to offer a theoretical basis for the wider clinical use of shock wave therapy. During the study, patients will be monitored at 6 weeks, 3 months, and 6 months after treatment using pain VAS scores, ASES scores, UCLA scores, and MRI evaluations to assess healing and shoulder function. Active shoulder range of motion will also be recorded at these times. Patients will complete exercise tests and questionnaires to track their progress. The total duration of follow-up is 6 months, with assessments focused on pain relief, function improvement, and tendon healing.

This research aims to evaluate the safety of using allogeneic umbilical cord-derived mesenchymal stem cells in patients undergoing arthroscopic rotator cuff repair for large to massive rotator cuff tears. It focuses on adults aged 19 and older who have significant shoulder pain and full-thickness tears that have not improved with conventional treatments. The study is sponsored by Korea University Anam Hospital and is designed to assess pain and tissue healing over a year. Participants receive a single injection of allogeneic umbilical cord-derived mesenchymal stem cells during their rotator cuff repair surgery. Two dosing options are studied: a low dose of 2.5x10 cells in 0.5 mL and a high dose of 5x10 cells in 1 mL. The injection is performed into the lesion using ultrasound guidance by the investigator. This treatment is given only once during the study period. Throughout the 12 months following treatment, participants will be monitored for pain during movement using the Visual Analog Scale (VAS) and changes in the size of their rotator cuff tears through MRI scans. Adverse events will also be tracked to assess safety. Participants will complete questionnaires and attend regular follow-up visits during the study. The total duration of participation spans one year from the intervention.

Researchers are studying how daily changes in mood, pain, and activity relate to acute and chronic pain using a smartphone app called SOMA. The study includes people with acute pain, chronic pain, and healthy controls. A smaller sub-study focuses on patients with chronic low back pain, failed back surgery syndrome, or fibromyalgia, using EEG testing to explore brain and behavior patterns that might predict treatment responses. Participants will use the SOMA app daily for four months to track their symptoms and activities. Those in the sub-study will also attend an in-person EEG session to perform specific tasks before starting app use. Data collected will help identify patterns linked to pain transition, recovery, or flare-ups. The study also monitors app engagement and symptom dynamics over up to 12 months. During the study, participants will report pain, mood, and activity daily through the app. Researchers will analyze these reports alongside baseline and follow-up EEG and behavioral tests. Outcomes include measuring the likelihood of acute pain becoming chronic and understanding mood and pain interactions. Participants' progress and app usage will be observed over time to assess feasibility and treatment effects.