Spondylolisthesis

Researchers are evaluating post-operative management approaches after a modified Lapidus arthrodesis surgery for hallux valgus, with or without additional surgeries such as Akin or WeilHohmann procedures. The study aims to compare the effectiveness and safety of immediate full weight-bearing versus partial weight-bearing 10-15 kg during rehabilitation. This randomized controlled trial explores a new rehabilitation method following foot surgery to improve recovery. Participants will be randomly assigned to one of two groups after surgery one group will follow partial weight-bearing with a specialized VACOPASO shoe and use crutches along with antithrombotic medication for 6 weeks, while the other group will have immediate complete weight-bearing with the same shoe and medication for the same period. The surgical operation follows standard clinical practices for hallux valgus correction. During the study, healing progress will be monitored through standard X-rays at 6, 12, and 24 weeks to check bone healing, hardware fixation, and fracture alignment. Pain will be measured using a Visual Analogue Scale at the day of surgery and at follow-up visits. Quality of life and functional recovery will be assessed through established foot and ankle scoring systems at multiple time points. The main outcome is the subjective functional recovery measured by the Olerud and Molander Ankle Score at 6 weeks post-surgery.

This research aims to create a pediatric robotic spine surgery registry to collect and analyze data on the combined use of robotics, navigation, and patient-specific rods in pediatric spine deformity surgery. The study includes children and young adults up to 21 years old with various spine deformities such as idiopathic scoliosis and spondylolisthesis. The goal is to establish an educational and informative framework for these advanced surgical technologies across participating institutions. Participants are patients scheduled for standard of care spine deformity surgery using robotics coupled with navigation andor patient-specific rods. The registry collects information during surgery and through follow-up assessments at baseline, 6 months, 1 year, 2 years, and 5 years. The study monitors various surgical and patient-reported outcomes to evaluate the technologys impact on surgery and recovery. During the study, participants undergo assessments including measurements of pedicle screw placement accuracy, radiation exposure, operative time, blood loss, and total operative costs at the time of surgery. Patient quality of life and physical function are tracked with several questionnaires up to five years post-surgery. This data helps researchers understand surgical outcomes and patient experiences over time, with the study continuing until 2031.

Researchers are studying different surgical methods for treating patients with symptomatic lumbar isthmic spondylolisthesis, a condition affecting the spine. The study compares anterior and posterior interbody fusion surgeries to determine which technique helps reduce leg pain the most. This research is important because doctors do not yet agree on the best surgical approach for this condition, and the study aims to clarify outcomes over time. The study involves two groups of patients who will receive either anterior or oblique interbody fusion surgery with various fixation methods, or posterior interbody fusion surgery using different surgical approaches. These surgeries involve placing devices like synthetic cages or bone grafts to stabilize the spine. The study will collect data over multiple years to assess the results of these surgical options. Participants will be monitored through regular follow-up visits at 1, 2, 5, and 10 years after surgery. Researchers will measure leg pain improvement using a numeric rating scale and track adverse events, reoperations, spinal alignment changes, and quality of life outcomes. The study also includes economic analyses to understand costs related to the surgeries and their effects on patient health and function.

Researchers are evaluating the effect of a student-led multimodal prehabilitation service called BoneFit for people preparing for total hip or knee replacement surgery. The study aims to improve physical and mental health, quality of life, and reduce hospital stay length, complications, and readmission rates for patients undergoing orthopedic surgery in the Hull region. This pilot feasibility study will compare BoneFit to usual care, as no prehabilitation service is currently offered locally. Participants in the BoneFit intervention group will receive a personalized care plan that includes exercise, nutrition, and psychological support tailored to their needs during the 8 weeks before surgery. A control group will receive usual care without intervention. The groups will be compared to assess the impact of the prehabilitation service. During the study, participants will undergo baseline tests and will be invited to repeat these assessments 3 months after surgery. Researchers will monitor recruitment, attendance, and acceptability over several years. They will also measure physical fitness, hospital length of stay, readmission rates, overall quality of life, and specific pain and function related to the knee or hip. The study will last up to 3 years, with ongoing follow-up assessments to evaluate outcomes.

This observational study is focused on collecting data about the performance of CERAMENT BONE VOID FILLER, a synthetic biphasic bone graft substitute, when used in typical medical practice for orthopedic disorders. The study is sponsored by BONESUPPORT AB and aims to gather information on device performance and patient outcomes to understand its use in real-world settings. Participants will receive CERAMENT BVF as part of their treatment at approved healthcare centers following the products instructions for use. Data collection includes monitoring unexpected device performance, complaints, adverse events, and serious adverse events during surgery and continuing up to 18 months after treatment. Radiological assessments, pain scores, and quality of life evaluations will be conducted at intervals throughout the study. During the study, participants will undergo scheduled reviews at 6, 12, and 18 months to assess device-related outcomes and healing progress using imaging and questionnaires. Researchers will track safety events and gather patient-reported outcomes such as pain levels and quality of life. Participation involves following up with healthcare providers over this period to provide ongoing data for comprehensive evaluation of the devices performance.

This research evaluates the clinical and radiological outcomes in patients who have undergone total ankle replacement for advanced ankle osteoarthritis. The study aims to assess results achieved by surgeons who did not originally design the implant, addressing potential bias seen in prior studies where designers performed the surgeries. The goal is to compare these outcomes with those of ankle arthrodesis, considering improvements in surgical techniques and ankle biomechanics knowledge. Participants in the study have received total ankle arthroplasty using a third-generation ankle replacement device. Clinical assessments are performed before and after surgery, with a minimum follow-up of 12 months. These include the American Orthopedic Foot and Ankle AOFAS score, the Foot Function Index, and the visual analogue scale VAS for pain. Weightbearing ankle X-rays are taken before surgery and at the final follow-up, with independent review by an orthopedic surgeon. During the study, participants complete scheduled follow-up evaluations, questionnaires, and radiographic exams. Researchers measure implant survivorship over 10 years along with various ankle joint angles and functional scores. The study monitors clinical progress, radiological changes, and foot function to evaluate long-term outcomes of the ankle replacement procedure.

Degenerative spine conditions are common in older adults and can cause significant health problems. When treatments like physiotherapy and pain medications dont work, surgery may be needed. This research focuses on a newer surgical method called unilateral biportal endoscopy UBE for lumbar decompression and aims to evaluate spinal stability after this procedure, especially since traditional surgeries sometimes lead to spine instability. The study involves patients aged 50 and older undergoing lumbar decompression surgery using the UBE technique. Researchers will assess spinal stability by performing dynamic X-rays three months after surgery. These X-rays will measure abnormal spine movement to determine if UBE surgery preserves spinal stability and potentially reduces the need for spinal fusion surgeries. Participants will have dynamic radiography before surgery and again three months afterward to check for spine movement and stability. The study will also track pain, disability, complications, and vertebral mobility at three months. The overall goal is to understand how well spinal stability is maintained after UBE surgery, with follow-up lasting at least three months post-operation.

Researchers are evaluating which medication, dexamethasone or dexmedetomidine, works better and is safer when added to a local anesthetic called ropivacaine in a nerve block named the erector spinae plane block ESPB. This nerve block helps reduce pain after lumbar spine surgery. This phase 4, randomized, double-blind trial aims to improve pain management while reducing opioid use and their side effects after spine surgery. All participants will undergo general anesthesia for lumbar spine surgery and receive a bilateral ESPB using ultrasound guidance. The nerve block will include ropivacaine combined with either dexamethasone, dexmedetomidine, or a placebo saline. Participants are randomly assigned to one of these three groups, and neither patients nor pain assessors will know which medication was used. During the study, researchers will monitor opioid use during the first 24 and 48 hours after surgery as the main outcome. They will also assess pain intensity at multiple time points, time to first pain relief, any nerve injuries, side effects such as nausea or low blood pressure, and laboratory markers like blood glucose and inflammation ratios. Participants are expected to stay in the hospital for at least 48 hours for monitoring and assessments.

Researchers are investigating the potential for bone fusion using ViviGen4 bone graft substitute compared to recombinant human bone morphogenetic protein-2 rhBMP-2 in patients undergoing specific spinal fusion surgeries, namely monosegmental anterior lumbar interbody fusion ALIF at L5S1 and extreme lateral interbody fusion XLIF at L45. The study aims to measure how well these treatments promote fusion and improve clinical outcomes in conditions like spondylosis, spondylolisthesis, and degenerative disc disease causing back andor leg pain. Participants are randomly assigned to receive either 5-5.4 cc of ViviGen4 or 4-6 mg of rhBMP-2 during their ALIF or XLIF spinal fusion surgery. Follow-up visits are scheduled at 14 days, 6 weeks, 6 months, and 12 months after surgery to evaluate the fusion progress and clinical outcomes. The study will assess the bone fusion rate using CT scans at 6 or 12 months, comparing the two treatments. The trial is monocentric and assessor-blinded, with a 11 ratio for the two treatment groups. During the study, participants will undergo radiological assessments including CT scans to confirm bone fusion and complete questionnaires to report back and leg pain, quality of life, disability in daily and work activities, and patient satisfaction. Safety and complications will be monitored at multiple time points. The primary outcome is the rate of interbody bony fusion confirmed by CT, with secondary outcomes focusing on pain levels, functional limitations, quality of life, and adverse effects. The total participation duration extends up to one year after surgery.

Researchers are evaluating surgical outcomes and best practice guidelines for adults with complex spinal deformities. This study focuses on patients with adult spinal deformity ASD, examining radiographic and clinical results, surgical and postoperative complications, risk factors for revision surgeries, and the impact of standard care processes on improving patient outcomes and reducing complications. The research aims to develop a universal system for classifying spine surgery complications and to understand factors affecting costs and mental health in ASD patients. The study involves multicenter, prospective observation of adults undergoing surgery for complex ASD, including those with congenital, degenerative, idiopathic, or iatrogenic spinal deformities. Complex cases are defined by specific radiographic measurements, extensive spinal fusion procedures, or geriatric criteria. Surgical interventions are determined by each patients treating surgeon and may include procedures like three-column osteotomies or anterior column reconstruction. Researchers also assess blood management, opioid use, frailty, and mental health as parts of the treatment process. Participants will undergo full-body EOS radiographic assessments before surgery, with follow-up evaluations at 3 months, 1, 2, 5, and 10 years. Outcomes are measured using various tools including the Scoliosis Research Society 22r questionnaire, Oswestry Disability Index, Veterans RAND 12, and PROMIS scales for anxiety, depression, pain, physical function, and social satisfaction. The study also tracks adverse events, frailty scores, and hospital stay lengths to understand long-term clinical and social health outcomes. The study will continue monitoring participants through 2032 to gather comprehensive data on surgical effectiveness and patient well-being.