Spondylolisthesis

Researchers are evaluating post-operative management approaches after a modified Lapidus arthrodesis surgery for hallux valgus, with or without additional surgeries such as Akin or Weil/Hohmann procedures. The study aims to compare the effectiveness and safety of immediate full weight-bearing versus partial weight-bearing (10-15 kg) during rehabilitation. This randomized controlled trial explores a new rehabilitation method following foot surgery to improve recovery. Participants will be randomly assigned to one of two groups after surgery: one group will follow partial weight-bearing with a specialized VACOPASO shoe and use crutches along with antithrombotic medication for 6 weeks, while the other group will have immediate complete weight-bearing with the same shoe and medication for the same period. The surgical operation follows standard clinical practices for hallux valgus correction. During the study, healing progress will be monitored through standard X-rays at 6, 12, and 24 weeks to check bone healing, hardware fixation, and fracture alignment. Pain will be measured using a Visual Analogue Scale at the day of surgery and at follow-up visits. Quality of life and functional recovery will be assessed through established foot and ankle scoring systems at multiple time points. The main outcome is the subjective functional recovery measured by the Olerud and Molander Ankle Score at 6 weeks post-surgery.

Researchers are investigating the use of ABM/P-15 bone graft compared to traditional bone graft in patients undergoing surgery for Adult Spinal Deformity (ASD). This study aims to improve clinical outcomes by promoting faster bone healing, reducing the need for additional surgeries, minimizing complications, and improving health-related quality of life. The trial is a prospective, randomized, controlled clinical study conducted at a specialized spine unit. Participants are randomly assigned to receive either the ABM/P-15 bone graft, which is a device combining anorganic bovine bone mineral with a synthetic peptide to enhance bone growth, or a standard bone graft made from locally harvested bone mixed with morselized allogenic femoral head. Both graft types are used during posterior spinal instrumentation and fusion surgery, with anterior support added as needed. The ABM/P-15 bone graft is placed on the spine structures and contained by the surrounding muscle. The study includes preoperative planning, surgery, and follow-up evaluations up to two years. Participants complete questionnaires before surgery and at 3 months, 1 year, and 2 years after surgery. They undergo X-rays at multiple time points and a CT scan one year after surgery to assess bone fusion and detect pseudarthrosis. Researchers track revision surgeries, adverse events, and cost-effectiveness during the study. Data on surgical details, complications, medication use, and rehabilitation are collected from medical records. The total participation lasts about two years, allowing for detailed assessment of outcomes and safety.

This research aims to create a pediatric robotic spine surgery registry to collect and analyze data on the combined use of robotics and navigation, along with patient-specific rods, in surgeries for pediatric spine deformities. The study includes patients diagnosed with various spine deformities such as idiopathic scoliosis, adolescent idiopathic scoliosis, spondylolisthesis, congenital scoliosis, and neuromuscular scoliosis. The goal is to establish an educational and informative framework for this technology across participating institutions. Participants will undergo standard-of-care spine deformity surgery that uses robotics coupled with navigation and/or patient-specific rods. The study focuses on observing these surgeries without introducing experimental treatments. Data will be gathered during surgery and at follow-up intervals to assess surgical precision and outcomes. During the study, researchers will track the precision of pedicle screw placement within 2 mm of cortical breach during surgery. They will also measure radiation exposure to patients and surgeons, operative time, blood loss, and total operative cost. Participants will complete several questionnaires at baseline, 6 months, 1 year, 2 years, and 5 years to evaluate physical activity, emotional distress, pain interference, peer relationships, and quality of life. The study follows participants for up to five years to monitor improvements in spine alignment and other health outcomes.

Researchers are studying different surgical methods for treating patients with symptomatic lumbar isthmic spondylolisthesis, a condition affecting the spine. The study compares anterior and posterior interbody fusion surgeries to determine which technique helps reduce leg pain the most. This research is important because doctors do not yet agree on the best surgical approach for this condition, and the study aims to clarify outcomes over time. The study involves two groups of patients who will receive either anterior or oblique interbody fusion surgery with various fixation methods, or posterior interbody fusion surgery using different surgical approaches. These surgeries involve placing devices like synthetic cages or bone grafts to stabilize the spine. The study will collect data over multiple years to assess the results of these surgical options. Participants will be monitored through regular follow-up visits at 1, 2, 5, and 10 years after surgery. Researchers will measure leg pain improvement using a numeric rating scale and track adverse events, reoperations, spinal alignment changes, and quality of life outcomes. The study also includes economic analyses to understand costs related to the surgeries and their effects on patient health and function.

Researchers are evaluating the effect of a student-led multimodal prehabilitation service called BoneFit for people preparing for total hip or knee replacement surgery. The study aims to improve physical and mental health, quality of life, and reduce hospital stay length, complications, and readmission rates for patients undergoing orthopedic surgery in the Hull region. This pilot feasibility study will compare BoneFit to usual care, as no prehabilitation service is currently offered locally. Participants in the BoneFit intervention group will receive a personalized care plan that includes exercise, nutrition, and psychological support tailored to their needs during the 8 weeks before surgery. A control group will receive usual care without intervention. The groups will be compared to assess the impact of the prehabilitation service. During the study, participants will undergo baseline tests and will be invited to repeat these assessments 3 months after surgery. Researchers will monitor recruitment, attendance, and acceptability over several years. They will also measure physical fitness, hospital length of stay, readmission rates, overall quality of life, and specific pain and function related to the knee or hip. The study will last up to 3 years, with ongoing follow-up assessments to evaluate outcomes.

This observational study is focused on collecting data about the performance of CERAMENT BONE VOID FILLER, a synthetic biphasic bone graft substitute, when used in typical medical practice for orthopedic disorders. The study is sponsored by BONESUPPORT AB and aims to gather information on device performance and patient outcomes to understand its use in real-world settings. Participants will receive CERAMENT BVF as part of their treatment at approved healthcare centers following the product's instructions for use. Data collection includes monitoring unexpected device performance, complaints, adverse events, and serious adverse events during surgery and continuing up to 18 months after treatment. Radiological assessments, pain scores, and quality of life evaluations will be conducted at intervals throughout the study. During the study, participants will undergo scheduled reviews at 6, 12, and 18 months to assess device-related outcomes and healing progress using imaging and questionnaires. Researchers will track safety events and gather patient-reported outcomes such as pain levels and quality of life. Participation involves following up with healthcare providers over this period to provide ongoing data for comprehensive evaluation of the device's performance.

This research evaluates the clinical and radiological outcomes in patients who have undergone total ankle replacement for advanced ankle osteoarthritis. The study aims to assess results achieved by surgeons who did not originally design the implant, addressing potential bias seen in prior studies where designers performed the surgeries. The goal is to compare these outcomes with those of ankle arthrodesis, considering improvements in surgical techniques and ankle biomechanics knowledge. Participants in the study have received total ankle arthroplasty using a third-generation ankle replacement device. Clinical assessments are performed before and after surgery, with a minimum follow-up of 12 months. These include the American Orthopedic Foot and Ankle (AOFAS) score, the Foot Function Index, and the visual analogue scale (VAS) for pain. Weightbearing ankle X-rays are taken before surgery and at the final follow-up, with independent review by an orthopedic surgeon. During the study, participants complete scheduled follow-up evaluations, questionnaires, and radiographic exams. Researchers measure implant survivorship over 10 years along with various ankle joint angles and functional scores. The study monitors clinical progress, radiological changes, and foot function to evaluate long-term outcomes of the ankle replacement procedure.

Degenerative spine conditions are common in older adults and can cause significant health problems. When treatments like physiotherapy and pain medications don’t work, surgery may be needed. This research focuses on a newer surgical method called unilateral biportal endoscopy (UBE) for lumbar decompression and aims to evaluate spinal stability after this procedure, especially since traditional surgeries sometimes lead to spine instability. The study involves patients aged 50 and older undergoing lumbar decompression surgery using the UBE technique. Researchers will assess spinal stability by performing dynamic X-rays three months after surgery. These X-rays will measure abnormal spine movement to determine if UBE surgery preserves spinal stability and potentially reduces the need for spinal fusion surgeries. Participants will have dynamic radiography before surgery and again three months afterward to check for spine movement and stability. The study will also track pain, disability, complications, and vertebral mobility at three months. The overall goal is to understand how well spinal stability is maintained after UBE surgery, with follow-up lasting at least three months post-operation.

Researchers are evaluating which medication, dexamethasone or dexmedetomidine, works better and is safer when added to a local anesthetic called ropivacaine in a nerve block named the erector spinae plane block (ESPB). This nerve block helps reduce pain after lumbar spine surgery. This phase 4, randomized, double-blind trial aims to improve pain management while reducing opioid use and their side effects after spine surgery. All participants will undergo general anesthesia for lumbar spine surgery and receive a bilateral ESPB using ultrasound guidance. The nerve block will include ropivacaine combined with either dexamethasone, dexmedetomidine, or a placebo (saline). Participants are randomly assigned to one of these three groups, and neither patients nor pain assessors will know which medication was used. During the study, researchers will monitor opioid use during the first 24 and 48 hours after surgery as the main outcome. They will also assess pain intensity at multiple time points, time to first pain relief, any nerve injuries, side effects such as nausea or low blood pressure, and laboratory markers like blood glucose and inflammation ratios. Participants are expected to stay in the hospital for at least 48 hours for monitoring and assessments.

Researchers are investigating the potential for bone fusion using ViviGen4 bone graft substitute compared to recombinant human bone morphogenetic protein-2 (rhBMP-2) in patients undergoing specific spinal fusion surgeries, namely monosegmental anterior lumbar interbody fusion (ALIF) at L5/S1 and extreme lateral interbody fusion (XLIF) at L4/5. The study aims to measure how well these treatments promote fusion and improve clinical outcomes in conditions like spondylosis, spondylolisthesis, and degenerative disc disease causing back and/or leg pain. Participants are randomly assigned to receive either 5-5.4 cc of ViviGen4 or 4-6 mg of rhBMP-2 during their ALIF or XLIF spinal fusion surgery. Follow-up visits are scheduled at 14 days, 6 weeks, 6 months, and 12 months after surgery to evaluate the fusion progress and clinical outcomes. The study will assess the bone fusion rate using CT scans at 6 or 12 months, comparing the two treatments. The trial is monocentric and assessor-blinded, with a 1:1 ratio for the two treatment groups. During the study, participants will undergo radiological assessments including CT scans to confirm bone fusion and complete questionnaires to report back and leg pain, quality of life, disability in daily and work activities, and patient satisfaction. Safety and complications will be monitored at multiple time points. The primary outcome is the rate of interbody bony fusion confirmed by CT, with secondary outcomes focusing on pain levels, functional limitations, quality of life, and adverse effects. The total participation duration extends up to one year after surgery.