Tonsillitis

Researchers are conducting a phase 1, first-in-human, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, and immune response of the VAX-A1 vaccine in healthy adults aged 18 to 40 years. The study aims to understand how the vaccine affects the immune system and monitor any side effects in this healthy young adult population. Participants are assigned to one of four groups receiving either low, mid, or high doses of VAX-A1 or placebo. Each participant receives two intramuscular injections, one on Day 1 and another at Month 2. The study follows a dose-escalation design to carefully evaluate different vaccine doses compared to placebo. Throughout the study, participants will be closely monitored for local and systemic reactions up to 7 days after each vaccination, as well as any adverse events for up to 8 months after the first dose. Blood samples will be collected at multiple time points to evaluate immune responses and safety laboratory tests. Participants will also complete an electronic diary to help track symptoms and reactions, with follow-up visits continuing through the study duration until 6 months after the second dose.

Adenoidectomy is the most common ear, nose, and throat surgery performed in children to remove lymphoid tissue from the nasopharynx and open the nasal airways. This procedure usually improves symptoms and quality of life, but some children may experience symptoms again due to leftover or regrown lymphoid tissue, which sometimes requires another surgery. The study aims to understand if individual patient factors like sex, age, weight, height, and soft palate length affect how well the traditional adenoidectomy technique removes this tissue. The traditional adenoidectomy is done without directly seeing the surgical area, often using instruments like an adenoid curette or Shambaugh adenotome. This method can sometimes leave residual tissue behind, which may cause symptom recurrence. This study observes pediatric patients undergoing this traditional surgical technique to evaluate how anatomical and individual factors relate to the completeness of tissue removal. Participants are children evaluated for adenoidectomy and followed for up to five years to assess surgical outcomes related to anatomical factors. Researchers will collect data on these patient-specific characteristics and monitor the presence of residual adenoid tissue after surgery. The main outcome measured is how these anatomical factors influence the success of the surgery over time, helping to clarify reasons behind tissue persistence or regrowth after the procedure.

Researchers are investigating autoinflammatory diseases AID, which involve recurring inflammatory episodes without infection, cancer, or adaptive immune system problems. This study focuses on both monogenic hereditary periodic syndromes and polygenic or multifactorial AID, including rare conditions like Behets disease, Still disease, Schnitzlers disease, PFAPA syndrome, chronic recurrent multifocal osteomyelitis, non-infectious uveitis and scleritis, among others. The goal is to gather detailed data to improve understanding and management of these rare diseases through an international collaboration. The study uses the AIDA registry, a secure online platform for collecting demographic, genetic, clinical, laboratory, radiologic, and therapeutic information. Data are gathered retrospectively and prospectively during routine clinical visits scheduled every 3-6 months. Eleven registries focus on different AID conditions, enabling comprehensive data collection to identify clinical patterns, treatment impacts, and long-term outcomes over a period of at least 10 years. Participants provide information during their usual care visits, allowing researchers to track changes in disease activity, organ involvement, inflammatory markers, visual function, pain levels, fatigue, fertility, and socioeconomic factors. The study monitors these outcomes over multiple timepoints up to 120 months. Data privacy is ensured by pseudonymizing patient information. This registry supports multiple clinical studies and aims to enhance knowledge, awareness, and future research on autoinflammatory diseases worldwide.

This research aims to evaluate whether using the Difflam Forte Anti-Inflammatory Throat Spray, containing benzydamine hydrochloride, can reduce the incidence and severity of postoperative sore throat POST in women undergoing gynecological surgery with general anesthesia using a laryngeal mask airway LMA. POST is a common issue caused mainly by mechanical injury to the airway mucosa during airway insertion, leading to inflammation and discomfort. The study will compare patients receiving Difflam spray after surgery to those receiving usual care with no intervention. Participants will be randomly assigned to one of two groups the study group will receive four sprays of Difflam to the back of the throat while awake in the post-anesthesia care unit, and the control group will receive no intervention. Questionnaires will be given to assess pain levels and any side effects 10 minutes and 4 hours after intervention. The trial will include 106 women undergoing surgery at a single hospital and will collect demographic and airway data during surgery. During the study, participants will be monitored for sore throat incidence and pain severity using a visual analog scale shortly after surgery and at 4 hours postoperatively. Side effects related to the spray will also be recorded. This information will help determine if Difflam spray is suitable for routine use to improve recovery and patient comfort after general anesthesia with LMA. The total study duration extends until the end of 2027.

Researchers are investigating whether a specific exercise program can reduce cancer recurrence and improve immune function in patients with head and neck cancer after surgery and chemoradiotherapy. The study focuses on the effects of exercise on immune aging immunosenescence, which is linked to higher risks of cancer and other diseases. This three-year project aims to find a safe and effective exercise routine that supports recovery and long-term health in these patients. Participants will be randomly assigned to either a group doing high-intensity interval training HIIT combined with resistance exercises two to three times a week, starting 4-5 weeks after chemoradiotherapy, or to a control group receiving no exercise intervention. The exercise program lasts for 8 weeks with 24-36 sessions. Researchers will monitor physical activity at home and track outcomes over three years. Throughout the study, participants will have blood tests to measure immune aging markers before and after the exercise program and at follow-up points. They will also complete quality of life questionnaires and have their physical fitness assessed by peak oxygen uptake measurements. Researchers will follow participants for cancer recurrence and survival, collecting data across the full three years to evaluate the effects of exercise on health and immune function.

This research aims to evaluate whether chewing gum and cold water gargling can ease common throat discomforts, such as sore throat and difficulty swallowing, experienced after bronchoscopy. The study compares these simple interventions against standard care to see if they improve patient comfort and satisfaction following the procedure. Participants will be randomly assigned to one of three groups chewing sugar-free xylitol gum for 15 minutes before bronchoscopy, gargling cold water 8-12C twice for 30 seconds each before the procedure, or receiving the usual care without additional treatments. The chewing gum and cold water gargle are supervised by researchers who provide instructions and ensure proper procedure. Participants symptoms and satisfaction will be assessed before bronchoscopy, then at 2 hours and 24 hours after the procedure. The 24-hour follow-up will be done by phone. Researchers will measure the severity of sore throat and swallowing difficulty along with patient satisfaction, aiming to understand if these interventions affect recovery and comfort. The study starts with standard fasting and includes routine education about bronchoscopy.

Researchers are evaluating whether stopping oral antibiotics when symptoms stop is as effective as completing the full prescribed course in children who have been treated with intravenous antibiotics for infections such as cellulitis, urinary tract infection UTI, lower respiratory tract infection LRTI, and lymphadenitis. This study is a phase 4, single-center, basket randomized controlled trial conducted at the Royal Childrens Hospital. It aims to determine if oral antibiotics can safely be stopped early in children with cellulitis and assess the feasibility of a larger study involving other infections. Participants will be randomly assigned to one of two groups those who stop oral antibiotics when symptoms resolve after completing at least 3 days of intravenous plus oral antibiotics, and those who finish the full course as per clinical guidelines. The study includes four groups based on infection type and begins with patients in the Hospital in the Home HITH program, expanding to inpatient wards. Daily symptom tracking is done by parents or guardians, and telehealth appointments are conducted once symptoms resolve. During the study, parents will complete a daily symptom diary while their child takes oral antibiotics and attend telehealth follow-ups after symptom resolution. Additional surveys occur on days 14, 28, and 180 to monitor clinical outcomes, reoccurrence, antibiotic use duration, antimicrobial resistance, and adverse events. The main outcome is the proportion of children who experience clinical failure within 28 days, defined as needing to restart antibiotics due to symptom return. The total study duration spans up to six months for follow-up assessments.

This research investigates the use of new versus reprocessed coblator wands during tonsillectomy and adenoidectomy surgeries in children. It aims to compare their efficiency, technical performance, and environmental impact, addressing the existing uncertainty about the reliability of reprocessed surgical tools. The study is randomized and double-blinded, involving pediatric patients undergoing these common surgical procedures. Participants will be randomly assigned to receive either new coblator ablation wands or reprocessed coblator wands that have been refurbished and sterilized. The study focuses on technical performance, including surgeon comfort following the procedure up to 4 hours. The evaluation also considers environmental and hospital cost aspects related to reprocessed versus new surgical tools. During the study, surgeons will assess their comfort with the coblator wands used in surgery. The research team will monitor and compare the performance and technical issues between the two wand types. The entire participation period occurs around the surgical procedure, with outcome measures collected shortly after surgery to inform on tool effectiveness and usability.

This research aims to gather detailed information about complicated infections treated by ear, nose, and throat ENT specialists in Ljubljana, Slovenia. It focuses on understanding how complicated infections of the sinuses, ears and temporal bone, neck soft tissues, and larynx are managed. The purpose is to improve treatment outcomes, shorten hospital stays, and develop clear clinical pathways for these diseases in Slovenia by comparing local data with other countries. Participants in this observational study will receive standard care according to established evidence-based clinical guidelines, which may include surgery andor conservative treatments. The study groups consist of patients with complicated infections in different ENT areas, including sinonasal infections, ear or temporal bone infections, neck soft tissue infections, and laryngeal infections. Treatments will be provided as usual without experimental interventions. During the study, researchers will collect data to create a database of patients treated at the University Medical Centre Ljubljana. They will monitor disease-free survival over 12 months and analyze treatment outcomes to provide transparent, ongoing information about managing these infections. Participation involves standard medical care and follow-up to assess recovery and complications, contributing to improved understanding and care quality over time.

This research aims to compare whether using different sizes of tracheal catheters causes less sore throat in women after thyroid surgery. It involves female patients aged 18 to 65 years with physical health status ranging from ASA I to III, all scheduled for thyroid surgery under general anesthesia. The study focuses on evaluating sore throat incidence and severity following the procedure. Participants are randomly assigned to one of three groups, each receiving a tracheal catheter with a different inner diameter 6.0 mm, 6.5 mm, or the traditional 7.0 mm size. The study monitors how each catheter size affects postoperative sore throat at multiple time points after surgery, specifically at 1 hour, 6 hours, 24 hours, and 48 hours. During the study, researchers record the presence and severity of sore throat at these times to assess differences among the groups. The trial includes women undergoing elective thyroid surgery under general anesthesia who meet the eligibility criteria. The study is expected to run until October 2026, with participant involvement mainly around the surgery and follow-up sore throat assessments.