Effectiveness of Benzydamine Hydrochloride Spray to Reduce Postoperative Sore Throat in Women Using Laryngeal Mask Airway During Surgery

What this Trial Is About

This research aims to evaluate whether using the Difflam Forte Anti-Inflammatory Throat Spray, containing benzydamine hydrochloride, can reduce the incidence and severity of postoperative sore throat POST in women undergoing gynecological surgery with general anesthesia using a laryngeal mask airway LMA. POST is a common issue caused mainly by mechanical injury to the airway mucosa during airway insertion, leading to inflammation and discomfort. The study will compare patients receiving Difflam spray after surgery to those receiving usual care with no intervention. Participants will be randomly assigned to one of two groups the study group will receive four sprays of Difflam to the back of the throat while awake in the post-anesthesia care unit, and the control group will receive no intervention. Questionnaires will be given to assess pain levels and any side effects 10 minutes and 4 hours after intervention. The trial will include 106 women undergoing surgery at a single hospital and will collect demographic and airway data during surgery. During the study, participants will be monitored for sore throat incidence and pain severity using a visual analog scale shortly after surgery and at 4 hours postoperatively. Side effects related to the spray will also be recorded. This information will help determine if Difflam spray is suitable for routine use to improve recovery and patient comfort after general anesthesia with LMA. The total study duration extends until the end of 2027.

Benzydamine Hydrochloride and Post-operative Sore Throat