Study of Brain Activity and Neural Connectivity in Adults With Acute Brain Injury and Unresponsive States Using Intracranial Electrodes

What this Trial Is About

Researchers are investigating brain activity patterns and seizure dynamics in patients with acute brain injury who have impaired consciousness. The study aims to better understand the neural networks involved in consciousness and improve diagnostic and prognostic tools during intensive care. It focuses on overcoming limitations of current EEG monitoring by using advanced intracranial electrodes for more precise brain activity measurement. Participants undergo placement of intracranial electrodes in the cortico-subcortical system to continuously monitor brain signals with high spatial and temporal resolution. This setup enables detection of seizures and study of thalamocortical network behavior in unresponsive patients. The study observes effects of brain stimulation and tracks neural profiles over time, including during the first 4 weeks after electrode implantation. During the study, participants receive continuous brain monitoring and behavioral assessments using the Coma Recovery Scale-Revised. Researchers measure seizure activity through intracranial and scalp EEG, analyze neural complexity, and evaluate responses to electrical stimulation. Long-term outcomes are assessed at 6 months and 1 year. The study supports improved patient stratification and may inform future treatments to aid recovery of consciousness.

Connectivity and Neural Signatures of Consciousness in Unresponsive States