Study of Coronary Artery Disease and Microvascular Disease in Different Types of Cardiomyopathies Tracking Heart Outcomes Over 5 Years

What this Trial Is About

Researchers are evaluating the long-term prognostic value of macrovascular and microvascular coronary artery stenoses in different types of cardiomyopathies, including ischemic, hypertrophic, dilated, and restrictive forms. The study aims to understand how bystander coronary artery disease and coronary microvascular disease affect outcomes in patients with these heart conditions. This observational research is conducted across five centers in France to provide insight into the impact of these diseases on cardiovascular prognosis. Participants with various cardiomyopathies will undergo coronary angiography, cardiac magnetic resonance imaging CMR, tomographic coronary artery angiography, single-photon emission computed tomography SPECT, and rest and stress trans-thoracic echocardiography TTE. Macrovascular coronary artery disease is defined by specific stenosis levels and ischemia confirmation, while microvascular disease is identified using indices like the index of microvascular resistance IMR and myocardial perfusion heterogeneity imaging MPHI. The study records these imaging results to evaluate their prognostic significance. During the study, major adverse cardiovascular events MACE will be assessed at 1 year, 2 years, and 5 years after enrollment. Participants are monitored through detailed cardiovascular imaging and clinical evaluations to track their health outcomes over time. This long-term follow-up will help researchers understand the relationship between coronary artery conditions and cardiomyopathy progression, contributing valuable information for patient care and management.

Coronary Artery Disease and Coronary Microvascular Disease in Cardiomyopathies Registry