Improving Diagnosis and Treatment of Non-Ischemic Cardiomyopathies with Arrhythmic and Inflammatory Features A Multicenter Observational Registry Study

What this Trial Is About

Researchers are studying a diverse group of heart muscle diseases known as non-ischemic cardiomyopathies NICM, which do not involve blocked coronary vessels but cause changes in the heart muscles structure and function. These include common types like dilated, hypertrophic, restrictive, and arrhythmogenic cardiomyopathies, as well as less common forms and overlapping or undefined types. The study focuses on two main patterns found in NICM arrhythmic issues, including dangerous heart rhythms, and inflammation of the heart muscle, both of which affect diagnosis, prognosis, and treatment options. The study collects data from past and current patients with suspected or confirmed NICM through a registry. Participants are divided into groups based on their clinical presentation those with arrhythmic symptoms and those without. Diagnostic methods include genetic tests, cardiac imaging such as MRI, CT scan, PET, biopsies, and electrophysiological tests to assess arrhythmias and inflammation. Treatments studied are tailored to each patient and may include medical therapies, implantable devices, immunosuppressive drugs, and procedures like catheter ablation, all evaluated by a multidisciplinary team. Participants clinical data and diagnostic results are gathered and analyzed over time to improve understanding of NICM. The study measures diagnostic accuracy of various tests at multiple time points up to 30 years. Researchers also look at the prevalence of inflammation and arrhythmias, correlations with genetic and imaging findings, risk prediction models, and treatment effects on heart events. This comprehensive approach aims to enhance diagnosis, risk assessment, and personalized treatment strategies for NICM patients.

Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.