Study of Coronary Blood Flow and Heart Function During Rapid Heartbeats in Patients Undergoing Coronary Angiography or Angioplasty

What this Trial Is About

Researchers are investigating why some patients tolerate ventricular tachycardia VT, a dangerous heart rhythm, better than others. The study focuses on how coronary artery disease affects VT tolerance and whether treating this disease with stents improves it. The goal is to understand factors that influence VT stability to help guide treatment decisions and possibly avoid the need for implantable cardioverter defibrillators ICDs. Participants undergoing coronary angiography or angioplasty will have blood pressure, coronary pressure, and coronary blood flow measured during simulated VT using rapid heart pacing. The study includes groups with normal coronary arteries, severe coronary artery disease awaiting stenting, microvascular dysfunction, and heart failure. Measurements will be taken before and after stenting to assess changes. During the study, participants will undergo clinically indicated coronary procedures while researchers collect cardiovascular measurements at various heart rates. These include blood pressure and coronary flow changes, with comparisons before and after stenting when applicable. The primary outcomes focus on how coronary flow and blood pressure vary during simulated VT in different patient groups. The study will continue until June 2026.

Coronary Flow During Rapid Heart Rates