Actively Recruiting
Coronary Epicardial and Microcirculatory Determinants of Ventricular Tachycardia Tolerability
Led by Imperial College London · Updated on 2026-03-27
70
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating why some patients tolerate ventricular tachycardia (VT), a dangerous heart rhythm, better than others. The study focuses on how coronary artery disease affects VT tolerance and whether treating this disease with stents improves it. The goal is to understand factors that influence VT stability to help guide treatment decisions and possibly avoid the need for implantable cardioverter defibrillators (ICDs). Participants undergoing coronary angiography or angioplasty will have blood pressure, coronary pressure, and coronary blood flow measured during simulated VT using rapid heart pacing. The study includes groups with normal coronary arteries, severe coronary artery disease awaiting stenting, microvascular dysfunction, and heart failure. Measurements will be taken before and after stenting to assess changes. During the study, participants will undergo clinically indicated coronary procedures while researchers collect cardiovascular measurements at various heart rates. These include blood pressure and coronary flow changes, with comparisons before and after stenting when applicable. The primary outcomes focus on how coronary flow and blood pressure vary during simulated VT in different patient groups. The study will continue until June 2026.
CONDITIONS
Brief Title
Coronary Flow During Rapid Heart Rates
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to give valid consent
- Referred for coronary angiography or coronary angioplasty
- Suitable for percutaneous physiological interrogation and PCI when clinically indicated
You will not qualify if you...
- Unable to give valid consent
- Pregnant or breastfeeding women
- Unstable coronary artery disease (acute coronary syndrome)
- Severe multivessel coronary artery disease suitable for coronary artery bypass grafting
- Severe heart valve disease
- Severe (NYHA IV) heart failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of coronary angiography procedure
Participants undergo coronary angiography during which blood pressure, coronary pressure, and coronary flow are measured during simulated ventricular tachycardia at a range of fast heart rates.
1 visit (in-person)
Duration - Same day as stenting procedure
In participants who receive stenting for coronary stenosis, measurements of blood pressure and coronary flow are repeated immediately before and after the stenting procedure to observe any changes.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Imperial College NHS Foundation Trust
London, United Kingdom, W12 0HS
Actively Recruiting
Research Team
R
Rahul Bahl
R
Ricardo Petraco
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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