Actively Recruiting
Research on Correlation Between Intestinal Microecology Imbalance and the Risk and Prognosis of Stroke in Young Adults
Led by Shanghai 6th People's Hospital · Updated on 2026-04-23
60
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the connection between imbalances in gut bacteria and stroke in young adults, a growing concern due to its rising incidence and significant impact on health and society. This observational study aims to explore how changes in intestinal microecology may influence the development and outcomes of stroke in people aged 18 to 45 years. The research uses advanced methods to analyze gut microbiota diversity and related biological markers to better understand stroke mechanisms and identify early risk factors in young patients. The study includes three groups: young adults who experienced their first acute ischemic stroke within 12 hours, those with their first acute hemorrhagic stroke within the same timeframe, and healthy young controls. By comparing these groups, researchers hope to identify specific gut flora patterns linked to stroke risk and prognosis. The study will apply multi-omics technologies such as metagenomics and metabonomics to achieve these goals. Participants will be monitored with assessments including the Modified Rankin Scale at 3 months after stroke to evaluate recovery and outcomes. Stool samples will be collected to analyze gut bacteria and metabolites. The research team will also collect clinical data to investigate the gut-brain axis's role in stroke. The study will continue until December 2027, with healthy volunteers also included for comparison.
CONDITIONS
Brief Title
Correlation Between Intestinal Microecology Imbalance and Stroke in Young Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of acute ischemic or hemorrhagic stroke
- Admission within 12 hours of stroke onset
- Aged 18 to 45 years
You will not qualify if you...
- History of neurological diseases, myocardial infarction, kidney or liver abnormalities, and metabolic diseases
- Presence of tumors, inflammatory bowel disease, or other digestive system diseases
- Presence of serious life-threatening conditions
- Use of antibiotics, probiotics, or prebiotics within the past 3 months
- Condition worsened or death before stool sample collection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 12 hours
Participants with stroke are evaluated within 12 hours of symptom onset to confirm diagnosis.
1 visit (in-person)
Duration - 3 months
Participants are monitored to assess stroke prognosis and related outcomes over time.
1 follow-up visit at 3 months
Trial Site Locations
Total: 2 locations
1
Shanghai 6th People's Hospital
Shanghai, China, 200233
Not Yet Recruiting
2
Shanghai 6th People's Hospital
Shanghai, China, 200233
Actively Recruiting
Research Team
H
Hao Chen, M.D., Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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