Study Investigating Memory CD8 T Cells and Their Impact on Sepsis Severity and Survival in Adults Aged 18 to 60

What this Trial Is About

Sepsis is a life-threatening condition caused by an uncontrolled response to infection, leading to organ dysfunction and high mortality, especially in critically ill patients in intensive care units. This observational study investigates how specific types of memory CD8 T cells, called Tcm and Tem, relate to the severity and survival outcomes of adults with sepsis. Researchers aim to understand the role of these immune cells in sepsis progression and patient prognosis. Participants include adults aged 18 to 60, both septic patients diagnosed within 24 hours of admission and healthy adults as controls. The study measures the quantity and growth of Tcm and Tem cells in blood samples collected at 0, 24, 48, and 72 hours after enrollment. Researchers compare these immune responses with clinical severity scores and mortality rates in the ICU. Throughout the study, participants will undergo blood tests to track CD8 T cell subsets and their activity over the first 72 hours after inclusion. The team will also monitor ICU length of stay, mechanical ventilation time, hospital length, mortality, and readmission rates up to four weeks. Additional assessments include organ failure scores and plasma cytokine levels, providing a comprehensive view of immune function and sepsis progression during critical illness.

Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective, Non-interventional, Observational Study