Clinical utility of BOLD-MRI in accurate diagnosis and prognostic evaluation of diabetic nephropathy: a prospective renal biopsy-based cohort study.
Qian Wang, Shaopeng Zhou, Yue Niu...
https://pubmed.ncbi.nlm.nih.gov/42008071Actively Recruiting
Age: 18Years +
All Genders
ID03865914
Correlation Study Between Clinical Phenotype and Pathology of Type 2 Diabetic Nephropathy
Led by Chinese PLA General Hospital · Updated on 2022-03-31
2000
Participants Needed
1
Research Sites
161 weeks
Total Duration
On this page
Sponsors
C
Chinese PLA General Hospital
Lead Sponsor
B
Beijing Municipal Science & Technology Commission
Collaborating Sponsor
AI-Summary
What this Trial Is About
Type 2 diabetes mellitus is the leading cause of end-stage renal disease due to diabetic nephropathy. This research investigates the differences between diabetic nephropathy (DN) and non-diabetic renal diseases (NDRD) in people with type 2 diabetes. The study aims to clarify the clinical and pathological features of type 2 diabetic kidney disease and develop criteria for clinical staging and prognosis since current staging is based on type 1 diabetic nephropathy. Participants will be grouped based on pathological results and clinical features such as kidney function and protein levels in urine. The study involves a long-term observation where the cohort will be followed for at least 10 years to analyze the correlation between clinical features and pathology. No treatments or interventions are provided as this is an observational study. Participants will be monitored through assessments of kidney function, specifically looking at changes in estimated glomerular filtration rate (eGFR) and urine protein over 24 months. Researchers will collect clinical data, including renal biopsy results and proteinuria levels, to evaluate disease progression. The study continues to track participants for outcomes related to kidney health over the extended follow-up period.
CONDITIONS
Brief Title
Correlation Study Between Clinical Phenotype and Pathology of Type 2 Diabetic Nephropathy
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Age 18 years or older, male or female
- Clinically diagnosed with type 2 diabetes mellitus
- Presence of kidney impairment including microalbuminuria, overt proteinuria, or renal insufficiency
- Kidney biopsy performed with complete pathological diagnosis
- Signed informed consent obtained from patients
You will not qualify if you...
- Incomplete disease history
- Clinically diagnosed with other secondary kidney diseases
- Presence of hereditary kidney disease
- Autoimmune diseases
- Malignant tumor expected survival less than 6 months
- Pregnancy or lactation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Long-term Monitoring
Duration - At least 10 years
Participants are followed to observe changes in kidney function and protein levels over time.
Trial Site Locations
Total: 1 location
1
Chinese PLA General Hospital
Beijing, Beijing Municipality, China, 100853
Actively Recruiting
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Research Team
X
Xiangmei Chen, MD.&Ph.D
Z
Zheyi Dong, MD.&Ph.D
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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WeiGuang Zhang, XiaoMin Liu, ZheYi Dong...
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https://pubmed.ncbi.nlm.nih.gov/35679002