Feasibility Study of Culturally Adapted Cognitive Behavioral Therapy Based Integrated Motivational Interviewing and Mindfulness Intervention for Substance Use Disorder in Pakistan (CAMIAB)

What this Trial Is About

Researchers are evaluating a culturally adapted version of Motivational Interviewing combined with Cognitive Behavioral Therapy (MICBT) and Mindfulness-Based Relapse Prevention (MBRP) for people with Substance Use Disorder (SUD) in Pakistan. The study aims to adapt these interventions to the local culture and test the feasibility and acceptability of the integrated approach called CAMIAB in a randomized control trial. This research involves both qualitative and quantitative methods across multiple phases. The study includes three main phases: first, cultural adaptation using focus groups and interviews with key stakeholders; second, testing the integrated MICBT and MBRP on a small group of 12 participants; and third, a feasibility factorial randomized control trial involving 260 participants from various hospitals and drug rehabilitation centers. Participants will receive one of four treatments: MICBT alone, MBRP alone, the integrated CAMIAB intervention, or routine care. Each intervention consists of 12 weekly sessions conducted in individual and group formats over 12 weeks. Participants will be assessed at the start, at the end of the 12-week intervention, and again 24 weeks after randomization. Assessments include feasibility and acceptability measures, as well as tools like the Maudsley Addiction Profile, Short Warwick-Edinburgh Mental Well-being Scale, EuroQol-5, and client service receipt inventory to track changes over time. Trained therapists will deliver the interventions with ongoing supervision, while masked research assistants will conduct outcome evaluations. The study runs until June 2025.

Culturally Adapted Motivational Interviewing With CBT and Mindfulness Based Relapse Prevention for Substance Use Disorder in Pakistan (CAMIAB)