Danish Diabetes Birth Registry 2 A Nationwide Cohort Study of Pregnancies Complicated by Pre-existing Diabetes Including Mothers, Partners, and Offspring

What this Trial Is About

Pregnancies in women with pre-existing diabetes, including type 1, type 2, and other types like MODY, are considered high risk and pose significant clinical challenges. The Danish Diabetes Birth Registry 2 (DDBR2) aims to create a nationwide cohort of these pregnancies to study both short- and long-term outcomes. This registry includes mother, partner, and child trios, combining registry, clinical data, and biological samples to better understand the impact of maternal diabetes on offspring health. The study collects extensive data from pregnant women with pre-existing diabetes, their partners, and offspring, including electronic patient records, continuous glucose monitoring data, ultrasound findings, and socioeconomic information. Biological samples are also gathered to explore genetic, epigenetic, and metabolic factors that may influence pregnancy outcomes and offspring health. The inclusion period runs from January 1, 2023, to December 31, 2027, with an expected 2,000 trios enrolled. Participants will be monitored throughout pregnancy and after delivery, with assessments including maternal HbA1c levels at 35 weeks, offspring birth weight adjusted for gestational age and gender, and continuous glucose monitoring metrics. Additional evaluations include maternal weight changes, pregnancy and birth complications, neonatal health, and quality of life measures. The study will use registry data, questionnaires, and biological analyses to identify predictors of maternal and neonatal outcomes and support future personalized treatments.

Danish Diabetes Birth Registry 2