Study of Severe Cerebral Vasospasm and Delayed Brain Infarction After Subarachnoid Hemorrhage Using Neuromonitoring and Treatments Including Induced Hypertension and Endoluminal Spasmolysis

What this Trial Is About

Researchers are observing patients who have severe cerebral vasospasm following a subarachnoid hemorrhage, either newly developing or already established. This study focuses on monitoring brain blood flow using multiple neuromonitoring methods to better understand delayed cerebral infarction beyond current treatments. The study is sponsored by Region Stockholm and aims to gather detailed data on blood flow velocity after certain interventions. The study involves treatments like induced hypertension using norepinephrine andor dobutamine to reach target cerebral perfusion pressure, following routine clinical guidelines. Another intervention is endoluminal spasmolysis, which uses intra-arterial Nimodipine to relax cerebral arteries as directed by neurointerventionists. These treatments are evaluated through observational monitoring rather than experimental assignment. Participants will be closely observed in a critical care setting after their subarachnoid hemorrhage. Researchers will measure mean flow velocity in cerebral arteries up to 12 hours after intervention, along with how long changes in flow velocity last after endoluminal spasmolysis. The study collects detailed neuromonitoring data while participants receive standard care, with the total involvement period depending on their clinical course.

Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension