The effect of early cognitive training and rehabilitation for patients with cognitive dysfunction in stroke.
Liu Xuefang, Wang Guihua, Miao Fengru
https://pubmed.ncbi.nlm.nih.gov/34132448Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID07588997
The Efficacy of Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Patients With Aneurysmal Subarachnoid Hemorrhage
Led by National Taiwan University Hospital · Updated on 2026-05-15
18
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of early motor-cognitive integrative training (e-MCIT) on cognitive and motor recovery in patients who have experienced aneurysmal subarachnoid hemorrhage (aSAH), a type of stroke caused by aneurysm rupture. This condition often leads to post-stroke cognitive impairments affecting memory, attention, executive function, and language, which impact patients' ability to perform daily activities and return to work. The study aims to better understand how combining motor and cognitive therapy soon after stroke can improve these outcomes compared to traditional early mobilization therapy. The study randomly assigns 18 adult patients with confirmed aSAH and cognitive impairment to either the e-MCIT group or a traditional early mobilization group. The e-MCIT involves simultaneous motor and cognitive training sessions lasting 30 minutes, 4-5 times per week until hospital discharge, while the traditional group receives motor-only training following a staged rehabilitation protocol. Both groups receive additional occupational and speech therapy as needed. The intervention starts in the intensive care unit (ICU) and continues through the subacute hospital phase. Participants undergo assessments at baseline, ICU discharge (about 2 weeks), hospital discharge (about 4 weeks), 3 months, and 1 year after intervention start. Evaluations include cognitive tests like the Montreal Cognitive Assessment, motor function scales, brain activity monitoring with functional near-infrared spectroscopy, and measures of daily living abilities, mood, and quality of life. Researchers will analyze changes over time to determine how the interventions impact cognitive and motor recovery, functional independence, and long-term reintegration into work and daily activities.
CONDITIONS
Brief Title
Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Patients With Aneurysmal Subarachnoid Hemorrhage
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosis of spontaneous subarachnoid hemorrhage caused by aneurysm rupture confirmed by CT scan or angiography
- Stroke onset in the acute phase, 2-7 days after medical intervention
- Age 18 years or older
- World Federation of Neurosurgical Societies (WFNS) score between 1 and 5
- Able to stand for more than 30 seconds
- Montreal Cognitive Assessment (MoCA) score below 26
You will not qualify if you...
- Unstable vital signs (e.g., heart rate outside 40-100 bpm, mean arterial pressure less than or equal to 80 mmHg, respiratory rate outside 12-20, oxygen saturation below 95%, intracranial pressure above 20 mmHg, cerebral perfusion pressure below 70 mmHg)
- Evaluated as unsuitable by attending physician
- Presence of other neurological diseases that may interfere with the study
- Less than 12 years of education
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Approximately 4 weeks until hospital discharge
Participants receive early motor-cognitive integrative training or early mobilization during their hospital stay, starting in the ICU and continuing through the general ward until discharge. The intervention consists of 30-minute sessions, conducted 4-5 times per week.
Multiple sessions weekly during hospital stay
Follow-up
Duration - Up to 1 year after hospital discharge
Participants undergo assessments of cognitive and motor function, daily living activities, and quality of life at 3 months and 1 year after hospital discharge to evaluate long-term outcomes.
2 follow-up visits (3-month and 1-year assessments), including a telephone interview at 1 year
Trial Site Locations
Total: 1 location
1
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University
Taipei, Taiwan, 100
Actively Recruiting
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Research Team
Y
Yan-ci Liu
P
Po-min Hsu
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Effects of Combined Cognitive and Exercise Interventions on Poststroke Cognitive Function: A Systematic Review and Meta-Analysis.
Ruifeng Sun, Xiaoling Li, Ziman Zhu...
https://pubmed.ncbi.nlm.nih.gov/34840972Understanding Cognitive Deficit After Subarachnoid Hemorrhage: A Memory Focused Approach.
Michael Alfonso, Saba Aftab, Tariq Hamadneh...
https://pubmed.ncbi.nlm.nih.gov/33354457Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association/American Stroke Association.
Nada El Husseini, Irene L Katzan, Natalia S Rost...
https://pubmed.ncbi.nlm.nih.gov/37125534Effect of early mobilization and rehabilitation on complications in aneurysmal subarachnoid hemorrhage.
Tanja Karic, Cecilie Røe, Tonje Haug Nordenmark...
https://pubmed.ncbi.nlm.nih.gov/27058204