Using Depth Electrodes to Detect Brain Activity Changes After Traumatic Brain Injury A Study with Novel Algorithms During Neurosurgical Treatment

What this Trial Is About

Researchers are evaluating the use of depth electrodes combined with new algorithms to detect cortical spreading depolarizations CSDs in patients who have suffered traumatic brain injury TBI requiring neurosurgical intervention. This study aims to understand how these brain signals relate to injury seen on imaging and could help improve diagnosis and treatment of secondary brain injury after TBI. During the standard surgical procedure to place an External Ventricular Drain EVD, a depth electrode will be inserted near the EVD catheter to record electrocorticogram ECoG activity. These recordings will be continuously monitored during the patients stay in the Intensive Care Unit ICU for up to about 14 days. The study will enroll 15 patients and use the collected data to develop a novel algorithm to detect CSDs. Participants will undergo the usual EVD placement surgery with the addition of the depth electrode. Their brain activity and physiological parameters will be recorded continuously during their clinical monitoring period. A neurosurgeon will review the ECoG data alongside imaging findings. The main outcome is to detect CSDs over a two-year period. The study is expected to take over 210 days to complete for all participants.

Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury