Actively Recruiting
Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
Led by University of Minnesota · Updated on 2026-02-23
15
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of depth electrodes combined with new algorithms to detect cortical spreading depolarizations (CSDs) in patients who have suffered traumatic brain injury (TBI) requiring neurosurgical intervention. This study aims to understand how these brain signals relate to injury seen on imaging and could help improve diagnosis and treatment of secondary brain injury after TBI. During the standard surgical procedure to place an External Ventricular Drain (EVD), a depth electrode will be inserted near the EVD catheter to record electrocorticogram (ECoG) activity. These recordings will be continuously monitored during the patient's stay in the Intensive Care Unit (ICU) for up to about 14 days. The study will enroll 15 patients and use the collected data to develop a novel algorithm to detect CSDs. Participants will undergo the usual EVD placement surgery with the addition of the depth electrode. Their brain activity and physiological parameters will be recorded continuously during their clinical monitoring period. A neurosurgeon will review the ECoG data alongside imaging findings. The main outcome is to detect CSDs over a two-year period. The study is expected to take over 210 days to complete for all participants.
CONDITIONS
Brief Title
Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient recommended to undergo EVD placement for the monitoring and possible treatment of Intracranial pressure (ICP) after TBI
You will not qualify if you...
- Contaminated scalp lacerations
- Known systemic infection
- Non-English speaking
- Fixed, uncorrectable coagulopathy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Approximately 14 days
Participants undergo neurosurgical intervention where a depth electrode is placed adjacent to the external ventricular drain during standard care for traumatic brain injury.
Continuous monitoring during clinically indicated neuromonitoring in the ICU
Trial Site Locations
Total: 1 location
1
Hennepin County Medical Center
Minneapolis, Minnesota, United States, 55415
Actively Recruiting
Research Team
D
David Darrow, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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