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Testing a Probiotic Y7, Tryptophan, and Branched-Chain Amino Acid Cocktail to Slow Early Parkinsons Disease Progression Using Preclinical Human Trials and Clinical Study in Patients Aged 30 to 85
Led by Taipei Medical University · Updated on 2026-06-02
120
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating a cocktail formula containing the probiotic Y7 combined with tryptophan and branched-chain amino acids in early-stage Parkinsons disease patients. This research aims to assess the effects of this supplement on motor, cognitive, and non-motor functions. The study will also develop a personalized prognosis prediction model for Parkinsons disease using clinical, biochemical, genetic, microbial, and metabolite data analyzed with machine learning to predict disease status 12 weeks after treatment. The trial is a two-arm, randomized controlled study involving 120 patients with Parkinsons disease stages 1 to 3. Participants are divided into an intervention group receiving the probiotic Y7 cocktail and a control group receiving a placebo. Both groups take two servings daily after breakfast and dinner for 12 weeks. Pre- and post-intervention assessments will be conducted to evaluate changes. Participants will undergo baseline assessments two weeks before starting the intervention and follow-up assessments two weeks after completion. Researchers will measure changes in motor and non-motor symptoms using questionnaires, cognitive tests like the Montreal Cognitive Assessment and Mini-Mental State Examination, sleep and constipation symptoms, nutritional status, body composition, dietary intake, gut microbiota, fecal and serum biomarkers, biochemical blood markers, immune profiles, and adverse events over the 12-week intervention. The study aims to understand treatment effects and predict individual disease progression.
CONDITIONS
Brief Title
Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
Research Team
H
Hui Yu Huang, PhD
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