Actively Recruiting
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude in Diqing Tibetan Autonomous Prefecture, Yunnan Province
Led by Ruijin Hospital · Updated on 2025-04-04
300
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how microbes interact with the human body, focusing on children's gut bacteria in different regions, altitudes, and diets. It studies the development and changes in gut bacteria of children living in high-altitude plateau areas and compares them with children living at low altitudes to explore links with immunity, metabolism, and growth. The goal is to provide scientific insights to improve children's health in high-altitude regions. Participants include children aged 1 to 3 years living either in high-altitude areas above 3000 meters or low-altitude areas below 500 meters. The study is observational and involves collecting fecal samples for gut microbiome and metabolite analysis within 7 days after enrollment. Researchers also use questionnaires to gather information on lifestyle, diet, and physical activity. During the study, children provide samples and may answer questions about their lifestyles. Researchers analyze the gut bacteria composition and metabolites to understand how these relate to growth and immune function. The study also monitors differences between children from high- and low-altitude regions. Participation involves cooperation from the child's legal guardian throughout the study process.
CONDITIONS
Brief Title
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 1-3 years old
- Both boys and girls
- The child's legal guardian has signed informed consent to participate
- The legal guardian agrees to follow study procedures and cooperate throughout the study
You will not qualify if you...
- Use of probiotics or antibiotics within the last month
- Significant abnormalities in liver, kidney, nervous system, respiratory, or blood clotting functions
- Unstable vital signs
- Presence of other underlying medical conditions
- Individuals considered unsuitable for the trial by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 0 to 7 days after enrollment
Participants provide fecal samples and answer questionnaires about lifestyle factors such as diet and physical activity to analyze gut microbiota composition and diversity.
1 to 2 visits for sample collection and questionnaires
Duration - Up to several months after initial evaluation
Participants are observed to assess the relationship between gut microbiota development and maturation with immunity, metabolism, and growth.
Additional assessments may occur depending on cohort assignment
Trial Site Locations
Total: 1 location
1
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China, 021
Actively Recruiting
Research Team
X
Xinqiong Wang
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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