Development of Cardiovascular Innovation Research Technologies Using Advanced Cardiac MRI to Study Heart Disease and Healthy Hearts

What this Trial Is About

Cardiovascular disease is the leading cause of death worldwide. Researchers are evaluating advanced cardiac MRI techniques that reveal detailed heart tissue characteristics, including inflammation, fibrosis, metabolism, and microstructural defects. This study aims to understand how these microstructural heart changes relate to heart function in both patients with cardiovascular disease and healthy individuals, comparing novel MRI technology with traditional clinical markers. Participants will undergo one of two MRI exams focusing on the heart either an extended clinical cardiac MRI that lasts about one hour including up to 25 minutes of additional research imaging, or a research cardiac MRI without contrast lasting one to two hours. Blood samples may be collected to correlate blood markers with MRI findings. Healthy volunteers will have a single non-contrast cardiac MRI. During the study, participants will have their heart images taken and may provide blood for research. Researchers will track heart muscle structure and function over up to 20 years using MRI. Medical records may be reviewed for up to 5 years after enrollment to follow health status. Blood samples, if collected, will be stored securely for up to 10 years. The main outcomes include measurements of heart muscle microstructure and function using advanced and conventional MRI techniques.

Development of CIRC Technologies