Actively Recruiting
Development of Cardiovascular Innovation Research Technologies
Led by The Cleveland Clinic · Updated on 2026-05-08
1000
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cardiovascular disease is the leading cause of death worldwide. Researchers are evaluating advanced cardiac MRI techniques that reveal detailed heart tissue characteristics, including inflammation, fibrosis, metabolism, and microstructural defects. This study aims to understand how these microstructural heart changes relate to heart function in both patients with cardiovascular disease and healthy individuals, comparing novel MRI technology with traditional clinical markers. Participants will undergo one of two MRI exams focusing on the heart: either an extended clinical cardiac MRI that lasts about one hour including up to 25 minutes of additional research imaging, or a research cardiac MRI without contrast lasting one to two hours. Blood samples may be collected to correlate blood markers with MRI findings. Healthy volunteers will have a single non-contrast cardiac MRI. During the study, participants will have their heart images taken and may provide blood for research. Researchers will track heart muscle structure and function over up to 20 years using MRI. Medical records may be reviewed for up to 5 years after enrollment to follow health status. Blood samples, if collected, will be stored securely for up to 10 years. The main outcomes include measurements of heart muscle microstructure and function using advanced and conventional MRI techniques.
CONDITIONS
Brief Title
Development of CIRC Technologies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Ability to provide written informed consent
- Diagnosed with cardiovascular disease if not a healthy volunteer
You will not qualify if you...
- Prisoners or other vulnerable populations
- Contraindications to MRI based on standard protocols
- Cognitive impairment or dementia affecting decision-making ability
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a cardiac MRI exam to determine and compare cardiac microstructural phenotypes. Healthy controls receive a single non-contrast MRI, while patients may receive an extended clinical cardiac MRI exam lasting up to one hour or a research cardiac non-contrast MRI exam lasting one to two hours. Blood samples may be collected for research purposes if participants agree.
1 visit (in-person)
Duration - Up to 5 years
Participants' medical records may be reviewed for up to 5 years after the MRI exam to follow-up on their medical status.
No additional visits; medical record review only
Trial Site Locations
Total: 1 location
1
Cardiovascular Innovation Research Center
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
C
CIRC Program Coordinator
C
CIRC Study Coordinator
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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