Diagnostic Performance of 4D Dynamic LAFOV FDG-PET Imaging for Differentiating Residual Disease and Post-Radiation Inflammation in Head and Neck Squamous Cell Carcinoma Treated by Radiotherapy

What this Trial Is About

Researchers are investigating the use of dynamic FDG-PET LAFOV imaging to distinguish between remaining cancer and inflammation caused by radiation treatment in patients with head and neck squamous cell carcinoma. This observational study focuses on evaluating imaging results at three months after completing curative radiotherapy. The study aims to improve the accuracy of therapeutic assessment in this patient group. Participants will undergo a dynamic 4D LAFOV FDG-PET scan three months after finishing their radiotherapy treatment. This advanced imaging technique collects detailed metabolic data to help identify whether residual disease or post-radiation inflammation is present. The study does not include any treatment interventions but monitors imaging and pathology characteristics related to the cancer and treatment response. During the study, patients will be assessed at three months post-radiotherapy with FDG-PET imaging and followed up for up to twelve months to record imaging dates, disease progression, and survival status. Researchers will analyze various imaging parameters including Ki and DV values derived from Patlak reconstruction methods. They will also collect data on tumor pathology and any post-radiation toxicity. The study participation involves monitoring and evaluation without additional therapeutic procedures.

Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.