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Daily Adaptive Radiotherapy for Head and Neck Squamous Cell Carcinoma Using Online Replanning and Optimization
Led by Rigshospitalet, Denmark · Updated on 2026-04-02
40
Participants Needed
1
Research Sites
52 weeks
Total Duration
AI-Summary
What this Trial Is About
Radiotherapy for head and neck squamous cell carcinoma often causes significant side effects. Researchers are evaluating if daily online adaptive radiotherapy, which adjusts the treatment plan each day to the patients changing anatomy, is feasible and can reduce radiation exposure to healthy organs, potentially lowering toxicity risks. Patients will receive daily online adaptive radiotherapy throughout their treatment. Each day, their radiotherapy treatment plan will be re-optimized after recontouring using the Siemens-Varian Ethos Platform to better target the cancer while protecting normal tissues. Participants will undergo daily treatment sessions with continuous monitoring. Researchers will assess the risk of swallowing difficulties dysphagia and dry mouth xerostomia six months after treatment using specific risk models. The study includes follow-up visits to evaluate treatment effects and safety over time.
CONDITIONS
Brief Title
A Study of Adaptive Radiotherapy of Head-neck Cancer Using Daily Replanning and Optimization of the Treatment Plan.
Research Team
J
Jeppe Friborg, MD, PhD
A
Anne Lindegaard, MD
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