Actively Recruiting
Daily Adaptive Radiotherapy of Head and Neck Cancer Using Siemens-Varian Ethos Platform
Led by Rigshospitalet, Denmark · Updated on 2026-04-02
40
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Radiotherapy for head and neck squamous cell carcinoma often causes significant side effects. Researchers are evaluating if daily online adaptive radiotherapy, which adjusts the treatment plan each day to the patient's changing anatomy, is feasible and can reduce radiation exposure to healthy organs, potentially lowering toxicity risks. Patients will receive daily online adaptive radiotherapy throughout their treatment. Each day, their radiotherapy treatment plan will be re-optimized after recontouring using the Siemens-Varian Ethos Platform to better target the cancer while protecting normal tissues. Participants will undergo daily treatment sessions with continuous monitoring. Researchers will assess the risk of swallowing difficulties (dysphagia) and dry mouth (xerostomia) six months after treatment using specific risk models. The study includes follow-up visits to evaluate treatment effects and safety over time.
CONDITIONS
Brief Title
A Study of Adaptive Radiotherapy of Head-neck Cancer Using Daily Replanning and Optimization of the Treatment Plan.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with histologically proven squamous cell carcinoma of the pharynx or larynx planned for primary radiotherapy with curative intent
- No current or earlier malignancies that may influence treatment, evaluation, or outcome of the head and neck cancer
- Informed consent as required by law
- Patient cannot participate in conflicting protocols
- Stage I-IV disease excluding T1-T2N0 carcinoma of the glottic larynx
- ECOG/WHO performance status 0-2
You will not qualify if you...
- Cancers of the glottic larynx (stage I/II), skull base, sino-nasal area, or unknown primary tumor
- Inability to attend full course of radiotherapy or follow-up visits in the outpatient clinic
- Presence of distant metastasis
- Previous radiotherapy of the head and neck
- Previous surgery for the primary cancer with curative intent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of the radiotherapy treatment course
Participants receive daily online adaptive radiotherapy for head and neck cancer, with treatment plans re-optimized daily using the Siemens-Varian Ethos Platform.
Daily visits for each treatment fraction
Duration - 6 months after treatment
Participants are monitored for risks of side effects such as dysphagia and xerostomia after completing treatment.
Follow-up visits as scheduled by the clinic
Trial Site Locations
Total: 1 location
1
Rigshospitalet
Copenhagen, Denmark
Actively Recruiting
Research Team
J
Jeppe Friborg, MD, PhD
A
Anne Lindegaard, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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