Diaphragm thickening in cardiac surgery: a perioperative prospective ultrasound study.
Pierre-Henri Moury, Adrien Cuisinier, Michel Durand...
https://pubmed.ncbi.nlm.nih.gov/31016412Actively Recruiting
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2024-10-09
130
Participants Needed
1
Research Sites
4 weeks
Total Duration
Researchers are investigating the potential of Diaphragmatic Inspiratory Amplitude (DIA) measured by ultrasound as a predictor for Post-Operative Pulmonary Complications (POPCs) in patients undergoing elective cardiac surgery. POPCs, which include pneumonia, atelectasis, and prolonged mechanical ventilation, pose significant risks such as increased morbidity, mortality, and healthcare costs. Diaphragmatic dysfunction, occurring in up to 20% of cardiac surgery patients, is linked to these respiratory complications but remains under-evaluated in this context. The study involves measuring DIA using ultrasound before surgery and on the first day after surgery on both sides of the diaphragm during quiet and deep breathing. Eight measurements per patient are taken to assess diaphragmatic movement. Standard cardiac surgery care, including anesthesia and monitoring protocols, continues as usual. Ultrasound measurements are conducted with specific probes to ensure consistent assessment, and postoperative care follows institutional protocols without influence from DIA results. Participants will be monitored for POPCs up to five days after surgery or until hospital discharge. Data collected include diaphragmatic movement measurements, clinical assessments, and diagnoses of pulmonary complications based on established guidelines. Measurements are taken when patients are comfortable and off mechanical ventilation or non-invasive ventilation. The primary outcome is to determine if DIA can predict POPCs, with outcomes reviewed by investigators unaware of DIA results to maintain impartiality.
CONDITIONS
Diaphragmatic Inspiratory Amplitude as a Prognosticator for Postoperative Pulmonary Complications After Cardiac Surgery
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo preoperative ultrasonographic measurements of their diaphragm function one day before elective cardiac surgery to establish baseline diaphragmatic inspiratory amplitude (DIA) values.
1 visit (in-person)
Duration - Surgery day plus immediate recovery period
Participants undergo elective cardiac surgery followed by immediate postoperative care in the Cardiac Surgical Recovery Unit (CSRU) as per standard institutional protocols.
1 hospital stay including surgery and recovery
Duration - 1 day
Participants have postoperative ultrasonographic measurements of diaphragmatic inspiratory amplitude (DIA) on postoperative day 1 in the CSRU to assess diaphragm function after surgery.
1 visit (in-person) in hospital
Duration - Up to 5 days or until hospital discharge
Participants are observed for postoperative pulmonary complications (POPCs) including pneumonia, atelectasis, and prolonged mechanical ventilation up to postoperative day 5 or hospital discharge, whichever occurs first.
Clinical monitoring during hospital stay
Total: 1 location
1
London Health Sciences Centre
London, Ontario, Canada
Actively Recruiting
R
Raffael Zamper, MD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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