Actively Recruiting
Diet-Induced Changes in GEnetic Material
Led by Pennington Biomedical Research Center · Updated on 2025-05-31
10
Participants Needed
1
Research Sites
163 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a pilot study in 10 men to test the hypothesis that perturbations in substrate flux and the circulating metabolic and pro-inflammatory milieus during a high-fat diet paradigm will modulate DNA methylation of genes in sperm associated with obesity and cardiometabolic dysfunction.
CONDITIONS
Official Title
Diet-Induced Changes in GEnetic Material
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male based on biological sex
- Age 20 to 35 years
- BMI between 18.5 and 24.9 kg/m2
- White/Caucasian
- Willing to consume pre-prepared meals
- Willing to wear an accelerometer and continuous glucose monitor
- Willing to track diet intake
- Willing to stay 24 hours, including overnight in a research clinic
- Willing to provide blood and sperm samples
- Willing to consent to whole-genome sequencing of DNA
You will not qualify if you...
- Unstable weight in the last 3 months (±15% weight loss or gain)
- Shift work or working in a factory setting
- Habitual smoking or use of tobacco products, including vaping, within the past 6 months
- History of clinically diagnosed diabetes
- Hypertension (>140/90 mmHg measured at screening)
- Has undergone bariatric surgery
- History of cardiovascular disease, neurological disease, or other chronic diseases, including cancer
- History of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)
- Adherence to special or restrained diets (e.g., low-CHO, low-fat, or vegetarian/vegan diets) or food allergies associated with study foods
- Currently engaging in >150 minutes moderate-intensity or >75 minutes of vigorous-intensity physical activity each week
- Drinking more than 14 servings of beer or alcohol per week
- Depressive (Score ≥10), anxiety (Score ≥8), and stress (Score≥15) symptomology (Score ≥16) from the 42-item Depression, Anxiety, Stress Scales (DASS)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
Research Team
E
Emily Flanagan, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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