Actively Recruiting
Direct Portal Pressure Measurement Via Endoscopic Ultrasound in Advanced Chronic Liver Disease (EVADIPP)
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-03-14
50
Participants Needed
1
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A minimally invasive procedure to directly assess portal pressure gradient under endoscopic ultrasound guidance (EUS-PPG) has become available and initial data have proved the technique to be safe. Aims of our proposal are: (i) to assess performance of EUS-PPG as compared to HVPG in evaluating hemodynamic response to non selective betablockers (NSBBs) in a large cohort of patients with CSPH;(ii) identification of markers of hemodynamic response(iii) identification of factors potentially affecting the accuracy of PPG measurement.
CONDITIONS
Official Title
Direct Portal Pressure Measurement Via Endoscopic Ultrasound in Advanced Chronic Liver Disease (EVADIPP)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with newly diagnosed esophago-gastric varices or with high suspicion of CSPH at non-invasive tests (porto- systemic collaterals at imaging, platelet count <150.000 x mm3, spleen size >13 cm in the largest axis, alteration of elastography parameters of the liver or spleen)
- Nafve to treatment with NSBBs
You will not qualify if you...
- Child Pugh >A6
- Hepatocellular carcinoma
- Portal vein thrombosis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Policlinico Gemelli IRCCS
Roma, Italy, 00168
Actively Recruiting
Research Team
F
Francesco Santopaolo, MD
CONTACT
E
Elisabetta Creta, SC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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