Actively Recruiting
Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches
Led by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Updated on 2026-03-30
230
Participants Needed
4
Research Sites
74 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Diagnosis of ALS/FTD disease spectrum is challenging because it largely relies on clinical symptoms. Identifying novel biomarkers is essential for a paradigm shift towards a more precise biological-based diagnosis. To achieve this aim, having access to proper specimens and analytical methods is crucial. Our team of experts in neurology, biology, chemistry, physics, and AI will explore ALS/FTD from novel perspectives using transcriptomics, proteomics, genomics and other innovative approaches to analyzing easily accessible tissues. The seed amplification assay (SAA) will be also exploited to detect pathological TDP-43. This project aims to create disease fingerprints useful for patient stratification and monitoring of disease progression, and to evaluate the therapeutic efficacy in clinical trials, thus overcoming the limits of clinical interpretation. Discovering new biomarkers and cellular pathways will improve the diagnosis and treatment of these devastating diseases.
CONDITIONS
Official Title
Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of ALS according to Brooks et al., 2000; de Carvalho M., 2008 criteria
- Clinical diagnosis of FTD according to GornoTempini et al., 2011; Rascovsky et al., 2011 criteria
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Italy, 20133
Actively Recruiting
2
Università degli Studi di Napoli "Federico II"
Naples, Italy, 80131
Not Yet Recruiting
3
Azienda Ospedaliero Universitaria di Sassari
Sassari, Italy, 07100
Not Yet Recruiting
4
Consorzio Interuniversitario Risonanze Magnetiche Metallo Proteine (CIRMMP)
Sesto Fiorentino, Italy, 50019
Not Yet Recruiting
Research Team
F
Fabio Moda, phd
CONTACT
A
Arianna Ciullini, phd
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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