Study of Brain Insulin Resistance and Its Impact on Brain Health in Adults with Type 1 and Type 2 Diabetes Aged 50 to 80

What this Trial Is About

Researchers are investigating how brain insulin resistance BIR may contribute to cognitive decline and dementia risk in people with diabetes. The study focuses on participants with type 1 diabetes, type 2 diabetes, and healthy controls aged 50 to 80 years. It aims to understand the link between BIR, brain blood vessel dysfunction, and brain health by combining cognitive testing with advanced brain imaging and metabolic analyses. Participants will undergo MRI brain scans to assess brain insulin response, structural changes, and cerebrovascular function. Intranasal insulin will be administered to evaluate cerebral perfusion. Additional tests include advanced MRI techniques for cerebrovascular assessments and functional MRI during glucose ingestion. Blood, urine, and stool samples will be collected for biomarker and multi-omics analyses to characterize BIR. During the study, participants will complete a comprehensive battery of cognitive tests covering memory, executive function, attention, and processing speed. Researchers will collect clinical data about diabetes duration and severity. They will measure brain insulin response and cerebrovascular reactivity and correlate these with cognitive performance. The study includes safety monitoring and will last until 2032, with baseline assessments performed once per participant.

Disentangling the Effect of Brain Insulin Resistance on Brain Health