A Multinational Observational Study on Early Rehabilitation Dosage and Outcomes in Adult Intensive Care Unit Patients

What this Trial Is About

This research aims to study the early rehabilitation and mobilisation practices for patients in intensive care units ICUs worldwide. It focuses on understanding how different mobilisation approaches affect physical function, functional status, and quality of life in ICU patients. The study addresses the issue of Intensive Care Unit Acquired Weakness ICUAW, which affects around 40% of ICU patients and leads to long-term functional limitations and reduced independence. Researchers want to find the best mobilisation dosage to improve patient outcomes, including those who were dependent before ICU admission or not on invasive mechanical ventilation. The study is a multinational, prospective observational trial involving over 6,000 patients from at least 200 ICUs. It does not involve any interventions but collects routine clinical and mobilisation data during ICU stays. Patients are categorized based on their functional independence before ICU admission. Participation lasts 90 days per patient, within a total study duration of 21 months. Standardized physical tests and questionnaires are used to assess patients mobility and function. Participants will have physical function assessed at ICU discharge and at 90 days, along with measurements of mobility level, frailty, length of ICU and hospital stay, mortality rates, disability, and activities of daily living. Data collection includes routine clinical information and mobilisation details documented during the ICU stay. The goal is to evaluate how mobilisation practices relate to patient recovery and long-term outcomes. The study is sponsored by the Medical University of Vienna and started in December 2025, with results expected by June 2027.

Dosage of Early Rehabilitation of ICU Patients