Actively Recruiting

Age: 18Years +
All Genders
NCT06931574

Double Kissing-crush vs Controlled Balloon-crush Techniques For Complex Coronary Bfurcation Lesions

Led by Istanbul Mehmet Akif Ersoy Educational and Training Hospital · Updated on 2025-04-17

300

Participants Needed

2

Research Sites

91 weeks

Total Duration

On this page

Sponsors

I

Istanbul Mehmet Akif Ersoy Educational and Training Hospital

Lead Sponsor

S

Sisli Hamidiye Etfal Training and Research Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

The Crush technique for coronary bifurcation lesions has evolved significantly since its introduction to the literature by Colombo et al. in 2003, with several iterations, including double kissing balloon inflation. The main disadvantage of the historical Crush technique is the low success rate of the final kissing balloon inflation. An improvement came with the introduction of double kissing crush stenting aiming for the shorter protrusion and kissing balloon dilation performed before and after main branch stent implantation. The double kissing crush provides a significant reduction in major adverse cardiovascular events compared to Provisional stenting, Crush, and Culotte techniques. Recently, a novel modified mini-crush technique (controlled balloon-crush) has been introduced to the literature and is one of the most up-to-date crush techniques. The main advantage of this technique over the contemporary mini-crush technique is that the side branch can be easily rewired, and the 1:1 size non-compliant balloon can easily pass through the crushed stent structure in the ostial part of the side branch. The basic rationale of this is that the crushing of the side branch stent is done in a more controlled manner (by slowly deflation of the side branch stent balloon), and this causes less disruption of the stent cells. To date, no data compares the mid-term outcomes of double kissing crush and controlled balloon-crush stenting techniques in patients with complex coronary bifurcation lesions. Hence, this study aimed to determine the clinical results of double kissing crush and controlled balloon-crush techniques under mid-term follow-up.

CONDITIONS

Official Title

Double Kissing-crush vs Controlled Balloon-crush Techniques For Complex Coronary Bfurcation Lesions

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged >18
  • Undergoing PCI with either double kissing crush or controlled balloon-crush technique
  • Presence of complex coronary bifurcation lesion (Medina 0.1.1 or 1.1.1)
Not Eligible

You will not qualify if you...

  • Non-complex bifurcation anatomy
  • Bail-out 2-stent procedure (reverse modified mini-crush)
  • ST-elevation myocardial infarction
  • Cardiogenic shock
  • In-stent restenosis
  • Previous coronary artery bypass grafting
  • Implantation of bare-metal stent
  • End-stage hepatic or renal disease
  • Life expectancy less than 1 year

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital

Istanbul, Turkey (Türkiye), 33484

Actively Recruiting

2

Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital

Istanbul, Turkey (Türkiye), 33484

Actively Recruiting

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Research Team

F

Fatih Uzun, Professor

CONTACT

A

Abdullah Doğan, MD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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