Actively Recruiting
Combined Coronary CT Angiography and CT Perfusion in Coronary Artery Disease: Integrating Plaque Morphology, Hemodynamics, and Perfusion for Precision Management
Led by Shanghai Zhongshan Hospital · Updated on 2025-04-29
2000
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the use of combined coronary computed tomography angiography (CTA) and CT myocardial perfusion (CTP) imaging to improve the diagnosis and management of coronary artery disease (CAD). This study addresses the limitations of CTA alone in assessing the functional significance of coronary lesions, especially in cases with borderline stenosis, severe calcification, or coronary microvascular dysfunction. It aims to evaluate the long-term prognostic value of integrating anatomical and functional imaging findings alongside AI-driven analysis to enhance personalized risk assessment and treatment decisions. The study observes patients undergoing either conservative management with medical therapy and lifestyle interventions or invasive coronary angiography (ICA) potentially combined with procedures like percutaneous coronary intervention (PCI), intravascular ultrasound (IVUS), optical coherence tomography (OCT), or fractional flow reserve (FFR). Imaging assessments include detailed plaque characterization and perfusion analysis using AI tools to quantify relevant markers. The research team will monitor clinical decisions influenced by imaging results, such as the need for revascularization or additional testing, and stratify patients into subgroups for further analysis. Participants will be followed over a five-year period to track major adverse cardiovascular events (MACE) and assess the predictive power of combined imaging biomarkers. Diagnostic accuracy of combined CTA/CTP will be compared with invasive reference standards within 30 days. Other evaluations include changes in myocardial perfusion related to symptom relief and the impact of severe calcification on diagnostic performance. The study involves comprehensive data collection on clinical outcomes, imaging metrics, and therapy adjustments to refine non-invasive approaches for CAD management.
CONDITIONS
Brief Title
Combined Coronary CT Angiography and CT Perfusion in Coronary Artery Disease (CoroFusion)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with an indication for CT myocardial perfusion imaging (CTP)
- Patients who have signed a written informed consent form
- Adults aged 18 years or older
You will not qualify if you...
- Left ventricular ejection fraction less than 35%
- Acute ST-elevation myocardial infarction within the past 3 months
- Previous coronary artery bypass graft surgery
- Planned coronary artery bypass graft surgery after diagnostic angiography
- Poor quality of CTA/CTP images unsuitable for analysis
- Contraindications for CT perfusion or coronary angiography
- Pregnancy, cancer, severe valvular heart disease, or liver/kidney dysfunction
- Other diseases with life expectancy less than one year
- Inability to sign informed consent or poor compliance likely to prevent study completion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 30 days
Participants undergo coronary CT angiography (CTA) and CT myocardial perfusion (CTP) imaging to assess coronary artery disease, including plaque characteristics and myocardial blood flow.
1 to 2 visits depending on imaging procedures
Duration - Up to 5 years
Participants are observed and clinical decisions are made based on imaging results, including medical therapy, lifestyle interventions, or invasive coronary angiography with possible interventions.
Periodic visits as per routine clinical care
Trial Site Locations
Total: 1 location
1
Zhongshan Hospital Fudan University
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
W
Wei Gao, PHD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here